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Gene Review

NCAPH  -  non-SMC condensin I complex, subunit H

Homo sapiens

Synonyms: BRRN, BRRN1, Barren homolog protein 1, CAP-H, CAPH, ...
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High impact information on NCAPH

  • We found that the association of hCAP-H, another non-SMC subunit of condensin I, with mitotic chromosomes depends on the presence of hCAP-D2 [1].
  • The symmetry of hCAP-H association with sister chromatids suggests that there are sequence-dependent domains of condensin aggregation [2].
  • Transcription of hCAP-H was restricted to proliferating cells with highest expression during the G(2) phase of the cell cycle [2].
  • Ultrastructural localizations of topoIIalpha and condensin I component hBarren (hBar; hCAP-H) in mitotic chromosomes were studied by immuno-EM [3].


  1. Contribution of hCAP-D2, a non-SMC subunit of condensin I, to chromosome and chromosomal protein dynamics during mitosis. Watrin, E., Legagneux, V. Mol. Cell. Biol. (2005) [Pubmed]
  2. Cell cycle-dependent expression and nucleolar localization of hCAP-H. Cabello, O.A., Eliseeva, E., He, W.G., Youssoufian, H., Plon, S.E., Brinkley, B.R., Belmont, J.W. Mol. Biol. Cell (2001) [Pubmed]
  3. Chromosome structure: improved immunolabeling for electron microscopy. Maeshima, K., Eltsov, M., Laemmli, U.K. Chromosoma (2005) [Pubmed]
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