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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LINC01565  -  long intergenic non-protein coding RNA 1565

Homo sapiens

Synonyms: C3orf27, GR6, Protein GR6
 
 
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High impact information on C3orf27

  • GR6 is activated in the UCSD-AML1 cell line and in a leukemic sample, both of which carry a t(3;3)(q21;q26) [1].
  • We have identified a novel gene, GR6, located within the leukemia breakpoint region of 3q21, that is normally expressed in early fetal development but not in adult peripheral blood [1].
  • Other genes that have been implicated at the rearrangement breakpoint are GR6 and RPN1 (both on 3q21) [2].

References

  1. Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Pekarsky, Y., Rynditch, A., Wieser, R., Fonatsch, C., Gardiner, K. Cancer Res. (1997) [Pubmed]
  2. Association of 3q21q26 syndrome with different RPN1/EVI1 fusion transcripts. Martinelli, G., Ottaviani, E., Buonamici, S., Isidori, A., Borsaru, G., Visani, G., Piccaluga, P.P., Malagola, M., Testoni, N., Rondoni, M., Nucifora, G., Tura, S., Baccarani, M. Haematologica (2003) [Pubmed]
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