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Gene Review

PRG4  -  p53-responsive gene 4

Homo sapiens

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High impact information on PRG4

  • OBJECTIVE: To determine whether the synovial fluid (SF) constituents hyaluronan (HA), proteoglycan 4 (PRG4), and surface-active phospholipids (SAPL) contribute to boundary lubrication, either independently or additively, at an articular cartilage-cartilage interface [1].
  • Articular cartilage provides a low-friction surface for joint articulation, with boundary lubrication facilitated by proteoglycan 4 (PRG4), which is secreted by chondrocytes of the superficial zone [2].
  • During monolayer culture, S cells retained their PRG4-secreting phenotype, whereas in alginate culture the percentage of cells secreting PRG4 decreased with time [2].
  • Lubricin, also known as superficial zone protein or PRG4, has many distinct biological functions, including lubrication, antiadhesion, and as a regulator of cell growth [3].

Analytical, diagnostic and therapeutic context of PRG4


  1. Boundary lubrication of articular cartilage: role of synovial fluid constituents. Schmidt, T.A., Gastelum, N.S., Nguyen, Q.T., Schumacher, B.L., Sah, R.L. Arthritis Rheum. (2007) [Pubmed]
  2. Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage. Klein, T.J., Schumacher, B.L., Blewis, M.E., Schmidt, T.A., Voegtline, M.S., Thonar, E.J., Masuda, K., Sah, R.L. Tissue Eng. (2006) [Pubmed]
  3. Mapping lubricin in canine musculoskeletal tissues. Sun, Y., Berger, E.J., Zhao, C., An, K.N., Amadio, P.C., Jay, G. Connect. Tissue Res. (2006) [Pubmed]
  4. Static and dynamic compression regulate cartilage metabolism of PRoteoGlycan 4 (PRG4). Nugent, G.E., Schmidt, T.A., Schumacher, B.L., Voegtline, M.S., Bae, W.C., Jadin, K.D., Sah, R.L. Biorheology. (2006) [Pubmed]
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