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MeSH Review

Cartilage, Articular

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Disease relevance of Cartilage, Articular


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Chemical compound and disease context of Cartilage, Articular


Biological context of Cartilage, Articular


Anatomical context of Cartilage, Articular


Associations of Cartilage, Articular with chemical compounds


Gene context of Cartilage, Articular


Analytical, diagnostic and therapeutic context of Cartilage, Articular


  1. Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease. Rizkalla, G., Reiner, A., Bogoch, E., Poole, A.R. J. Clin. Invest. (1992) [Pubmed]
  2. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. Neuhold, L.A., Killar, L., Zhao, W., Sung, M.L., Warner, L., Kulik, J., Turner, J., Wu, W., Billinghurst, C., Meijers, T., Poole, A.R., Babij, P., DeGennaro, L.J. J. Clin. Invest. (2001) [Pubmed]
  3. Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Jiménez, M.J., Balbín, M., López, J.M., Alvarez, J., Komori, T., López-Otín, C. Mol. Cell. Biol. (1999) [Pubmed]
  4. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Little, C.B., Hughes, C.E., Curtis, C.L., Jones, S.A., Caterson, B., Flannery, C.R. Arthritis Rheum. (2002) [Pubmed]
  5. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. Johnson, K.A., Terkeltaub, R.A. J. Biol. Chem. (2005) [Pubmed]
  6. Delayed formation of proteoglycan aggregate structures in human articular cartilage disease states. Oegema, T.R. Nature (1980) [Pubmed]
  7. Effects of oral administration of type II collagen on rheumatoid arthritis. Trentham, D.E., Dynesius-Trentham, R.A., Orav, E.J., Combitchi, D., Lorenzo, C., Sewell, K.L., Hafler, D.A., Weiner, H.L. Science (1993) [Pubmed]
  8. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. Lark, M.W., Bayne, E.K., Flanagan, J., Harper, C.F., Hoerrner, L.A., Hutchinson, N.I., Singer, I.I., Donatelli, S.A., Weidner, J.R., Williams, H.R., Mumford, R.A., Lohmander, L.S. J. Clin. Invest. (1997) [Pubmed]
  9. Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. Clancy, R.M., Rediske, J., Tang, X., Nijher, N., Frenkel, S., Philips, M., Abramson, S.B. J. Clin. Invest. (1997) [Pubmed]
  10. Comparison of phosphohydrolase activities from articular cartilage in calcium pyrophosphate deposition disease and primary osteoarthritis. Tenenbaum, J., Muniz, O., Schumacher, H.R., Good, A.E., Howell, D.S. Arthritis Rheum. (1981) [Pubmed]
  11. Staphylococcus aureus stimulates inducible nitric oxide synthase in articular cartilage. Jang, D., Williams, R.J., Wang, M.X., Wei, A.Q., Murrell, G.A. Arthritis Rheum. (1999) [Pubmed]
  12. Alizarin red S staining as a screening test to detect calcium compounds in synovial fluid. Paul, H., Reginato, A.J., Schumacher, H.R. Arthritis Rheum. (1983) [Pubmed]
  13. Modulation of native chondroitin sulphate structure in tissue development and in disease. Caterson, B., Mahmoodian, F., Sorrell, J.M., Hardingham, T.E., Bayliss, M.T., Carney, S.L., Ratcliffe, A., Muir, H. J. Cell. Sci. (1990) [Pubmed]
  14. Expression of type X collagen and matrix calcification in three-dimensional cultures of immortalized temperature-sensitive chondrocytes derived from adult human articular cartilage. Oyajobi, B.O., Frazer, A., Hollander, A.P., Graveley, R.M., Xu, C., Houghton, A., Hatton, P.V., Russell, R.G., Stringer, B.M. J. Bone Miner. Res. (1998) [Pubmed]
  15. Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis. Ray, A., Kuroki, K., Cook, J.L., Bal, B.S., Kenter, K., Aust, G., Ray, B.K. Arthritis Rheum. (2003) [Pubmed]
  16. Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa. Johnson, K., Hashimoto, S., Lotz, M., Pritzker, K., Terkeltaub, R. Am. J. Pathol. (2001) [Pubmed]
  17. The keratan sulfate-enriched region of bovine cartilage proteoglycan consists of a consecutively repeated hexapeptide motif. Antonsson, P., Heinegård, D., Oldberg, A. J. Biol. Chem. (1989) [Pubmed]
  18. Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse. Cuzzocrea, S., Mazzon, E., di Paola, R., Genovese, T., Patel, N.S., Britti, D., de Majo, M., Caputi, A.P., Thiemermann, C. Arthritis Rheum. (2005) [Pubmed]
  19. Evidence for a negative Pasteur effect in articular cartilage. Lee, R.B., Urban, J.P. Biochem. J. (1997) [Pubmed]
  20. Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage. Aigner, T., Bertling, W., Stöss, H., Weseloh, G., von der Mark, K. J. Clin. Invest. (1993) [Pubmed]
  21. Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. van den Berg, W.B., van de Putte, L.B., Zwarts, W.A., Joosten, L.A. J. Clin. Invest. (1984) [Pubmed]
  22. Histologic localization of lipid in the articular tissues in calcium pyrophosphate dihydrate crystal deposition disease. Ohira, T., Ishikawa, K., Masuda, I., Yokoyama, M., Honda, I. Arthritis Rheum. (1988) [Pubmed]
  23. Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K. Morko, J., Kiviranta, R., Joronen, K., Säämänen, A.M., Vuorio, E., Salminen-Mankonen, H. Arthritis Rheum. (2005) [Pubmed]
  24. Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice. Zemmyo, M., Meharra, E.J., Kühn, K., Creighton-Achermann, L., Lotz, M. Arthritis Rheum. (2003) [Pubmed]
  25. Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid. Villiger, P.M., Terkeltaub, R., Lotz, M. J. Clin. Invest. (1992) [Pubmed]
  26. Localization of collagenase in the growth plate of rachitic rats. Dean, D.D., Muniz, O.E., Berman, I., Pita, J.C., Carreno, M.R., Woessner, J.F., Howell, D.S. J. Clin. Invest. (1985) [Pubmed]
  27. Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keratan sulfate. Zanetti, M., Ratcliffe, A., Watt, F.M. J. Cell Biol. (1985) [Pubmed]
  28. Synthesis of cartilage matrix by mammalian chondrocytes in vitro. III. Effects of ascorbate. Daniel, J.C., Pauli, B.U., Kuettner, K.E. J. Cell Biol. (1984) [Pubmed]
  29. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Ohshima, S., Saeki, Y., Mima, T., Sasai, M., Nishioka, K., Nomura, S., Kopf, M., Katada, Y., Tanaka, T., Suemura, M., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  30. Integrin-regulated secretion of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes. Millward-Sadler, S.J., Wright, M.O., Lee, H., Nishida, K., Caldwell, H., Nuki, G., Salter, D.M. J. Cell Biol. (1999) [Pubmed]
  31. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. Yang, X., Chen, L., Xu, X., Li, C., Huang, C., Deng, C.X. J. Cell Biol. (2001) [Pubmed]
  32. Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis. Ishiguro, N., Ito, T., Oguchi, T., Kojima, T., Iwata, H., Ionescu, M., Poole, A.R. Arthritis Rheum. (2001) [Pubmed]
  33. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Wu, W., Billinghurst, R.C., Pidoux, I., Antoniou, J., Zukor, D., Tanzer, M., Poole, A.R. Arthritis Rheum. (2002) [Pubmed]
  34. Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Bau, B., Gebhard, P.M., Haag, J., Knorr, T., Bartnik, E., Aigner, T. Arthritis Rheum. (2002) [Pubmed]
  35. The role of link protein in mediating the interaction between hyaluronic acid and newly secreted proteoglycan subunits from adult human articular cartilage. Melching, L.I., Roughley, P.J. J. Biol. Chem. (1985) [Pubmed]
  36. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Williams, J.M., Brandt, K.D. Arthritis Rheum. (1985) [Pubmed]
  37. Functional estrogen receptors in adult articular cartilage: estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2. Richmond, R.S., Carlson, C.S., Register, T.C., Shanker, G., Loeser, R.F. Arthritis Rheum. (2000) [Pubmed]
  38. Expression of clusterin in the superficial zone of bovine articular cartilage. Khan, I.M., Salter, D.M., Bayliss, M.T., Thomson, B.M., Archer, C.W. Arthritis Rheum. (2001) [Pubmed]
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