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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TMEM245  -  transmembrane protein 245

Homo sapiens

Synonyms: C9orf5, CG-2, CG2, Protein CG-2, Transmembrane protein 245
 
 
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Disease relevance of C9orf5

 

High impact information on C9orf5

  • Genomic analysis of CG-2 identified 18 exons that span more than 110kb [1].
  • CG-2 was detected as a relatively abundant 8kb transcript in all adult and fetal tissues with the exception of adult thymus [1].
  • It was found that in Ca(2+) free solutions, CG-2 exists primarily as a highly quenched intramolecular dimer, but when bound to Ca(2+), the molecule adopts an extended, fluorescent conformation [2].
 

Analytical, diagnostic and therapeutic context of C9orf5

References

  1. Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene. Chadwick, B.P., Gill, S., Leyne, M., Mull, J., Liebert, C.B., Robbins, C.M., Pinkett, H.W., Makalowska, I., Maayan, C., Blumenfeld, A., Axelrod, F.B., Brownstein, M., Slaugenhaupt, S.A. Gene (1999) [Pubmed]
  2. Ensemble and single-molecule fluorescence spectroscopy of a calcium-ion indicator dye. Bagh, S., Paige, M.F. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
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