Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MTCH1 - mitochondrial carrier 1

Homo sapiens

Synonyms: CGI-64, Mitochondrial carrier homolog 1, PIG60, PSAP, Presenilin-associated protein, ...

Jeyaraju, D.V. et al., Leissring, M.A. et al., Berezovska, O. et al.

Berezovska, Jack, McLean, Aster, Hicks, Xia, Wolfe, Weinmaster, Selkoe, Hyman,

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High impact information on MTCH1

Here we show that phosphorylation and cleavage of the vertebrate-specific Pbeta domain of the mammalian presenilin-associated rhomboid-like (PARL) protease can influence mitochondrial morphology [1].
The finding that mutations in both PS1 and PS2 modulate intracellular calcium signaling suggests that these disturbances may represent a common pathogenic mechanism of presenilin-associated FAD [2].
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity [3].

References

Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology. Jeyaraju, D.V., Xu, L., Letellier, M.C., Bandaru, S., Zunino, R., Berg, E.A., McBride, H.M., Pellegrini, L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. Leissring, M.A., Parker, I., LaFerla, F.M. J. Biol. Chem. (1999) [Pubmed]
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Berezovska, O., Jack, C., McLean, P., Aster, J.C., Hicks, C., Xia, W., Wolfe, M.S., Weinmaster, G., Selkoe, D.J., Hyman, B.T. Ann. N. Y. Acad. Sci. (2000) [Pubmed]

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MTCH1	Bos taurus
MTCH1	Macaca mulatta
Mtch1	Mus musculus
Mtch1	Rattus norvegicus

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