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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pde5a  -  phosphodiesterase 5A, cGMP-specific

Mus musculus

Synonyms: CGB-PDE, Cgbpde, Cn5n, PDE5A1, Pde5, ...
 
 
 
 
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High impact information on Pde5a

  • In addition, caspase-3 induced an approximately 80% reduction in the activity of a partially purified preparation of PDE5A1 in the presence of rod PDEgamma [1].
  • In contrast with both PDE6 and PDE5A1, rod PDEgamma was without effect on this enzyme [1].
 

Other interactions of Pde5a

  • We have investigated whether the proteolysis of members of the cGMP binding phosphodiesterases (PDE6, PDE5A1, and PDE10A2) by caspase-3 is modulated by the gamma inhibitor subunit of PDE6 [1].

References

  1. The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3. Frame, M., Wan, K.F., Tate, R., Vandenabeele, P., Pyne, N.J. Cell. Signal. (2001) [Pubmed]
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