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PDE5A  -  phosphodiesterase 5A, cGMP-specific

Canis lupus familiaris

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High impact information on PDE5A

  • Whole myocardium from failing hearts had 50% lower PDE5A protein expression and 30% less total and EMD92639-inhibitable cGMP-PDE activity [1].
  • In normal conscious dogs chronically instrumented for left ventricular pressure-dimension analysis, PDE5A inhibition by EMD82639 had modest basal effects but markedly blunted dobutamine-enhanced systolic and diastolic function [1].
  • Immunohistochemistry confirmed PDE5A expression in both the vasculature and myocytes of normal and failing hearts, but there was loss of z-band localization in failing myocytes that suggested altered intracellular localization [1].


  1. Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure. Senzaki, H., Smith, C.J., Juang, G.J., Isoda, T., Mayer, S.P., Ohler, A., Paolocci, N., Tomaselli, G.F., Hare, J.M., Kass, D.A. FASEB J. (2001) [Pubmed]
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