Gene Review:
PDE5A - phosphodiesterase 5A, cGMP-specific
Bos taurus
- Probing domain functions of chimeric PDE6alpha'/PDE5 cGMP-phosphodiesterase. Granovsky, A.E., Natochin, M., McEntaffer, R.L., Haik, T.L., Francis, S.H., Corbin, J.D., Artemyev, N.O. J. Biol. Chem. (1998)
- Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation. Ni, X.P., Safai, M., Gardner, D.G., Humphreys, M.H. Kidney Int. (2001)
- Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Broderick, K.E., Kean, L., Dow, J.A., Pyne, N.J., Davies, S.A. J. Biol. Chem. (2004)
- The GAFa domains of rod cGMP-phosphodiesterase 6 determine the selectivity of the enzyme dimerization. Muradov, K.G., Boyd, K.K., Martinez, S.E., Beavo, J.A., Artemyev, N.O. J. Biol. Chem. (2003)
- Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). Fink, T.L., Francis, S.H., Beasley, A., Grimes, K.A., Corbin, J.D. J. Biol. Chem. (1999)
- Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). Turko, I.V., Francis, S.H., Corbin, J.D. J. Biol. Chem. (1999)
- Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation. Turko, I.V., Francis, S.H., Corbin, J.D. Biochem. J. (1998)
- Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Turko, I.V., Ballard, S.A., Francis, S.H., Corbin, J.D. Mol. Pharmacol. (1999)
- cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5. Kotera, J., Grimes, K.A., Corbin, J.D., Francis, S.H. Biochem. J. (2003)
- cAMP-dependent induction of PDE5 expression in murine neuroblastoma cell differentiation. Giordano, D., Giorgi, M., Sette, C., Biagioni, S., Augusti-Tocco, G. FEBS Lett. (1999)
- Altered expression of cyclic nucleotide phosphodiesterase isozymes during culture of aortic endothelial cells. Ashikaga, T., Strada, S.J., Thompson, W.J. Biochem. Pharmacol. (1997)
- Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities. Corbin, J.D., Turko, I.V., Beasley, A., Francis, S.H. Eur. J. Biochem. (2000)
- Antimitogenic actions of organic nitrates are potentiated by sildenafil and mediated via activation of protein kinase A. Osinski, M.T., Rauch, B.H., Schrör, K. Mol. Pharmacol. (2001)
- The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. Daugan, A., Grondin, P., Ruault, C., Le Monnier de Gouville, A.C., Coste, H., Linget, J.M., Kirilovsky, J., Hyafil, F., Labaudinière, R. J. Med. Chem. (2003)
- Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle. Murthy, K.S. Biochem. J. (2001)
- A photoaffinity probe covalently modifies the catalytic site of the cGMP-binding cGMP-specific phosphodiesterase (PDE-5). Corbin, J.D., Beasley, A., Turko, I.V., Haik, T.L., Mangum, K.A., Wells, J.N., Francis, S.H., Sekhar, K.R. Cell Biochem. Biophys. (1998)