Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Andpro - androgen regulated protein

Rattus norvegicus

Synonyms: Androgen-regulated 20 kDa protein, CRP-1, Crp1, Cystatin-related protein 1, Prostatic 22 kDa glycoprotein P22K16/P22K20, ...

Vercaeren, I. et al., Devos, A. et al., Ho, K.C. et al.

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High impact information on Andpro

The androgen-regulated 20-kDa protein gene consists of four exons that code for a major secretory protein of rat ventral prostate [1].
In both glands, the CRP-1 messenger RNA (mRNA)s are androgen regulated [2].
In the less abundant shorter form (CRP-1 delta), 123 nucleotides are deleted by alternative splicing at the junction between the third and the fourth exon [2].
Two complete 6-kb genes, Crp1 and Crp2, have been cloned and characterized [3].

Biological context of Andpro

The 5' flanking regions of Crp1 and Crp2 are highly homologous and contain a GATAAA sequence 29 nt upstream from the transcription start point [3].

References

A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity. Ho, K.C., Marschke, K.B., Tan, J., Power, S.G., Wilson, E.M., French, F.S. J. Biol. Chem. (1993) [Pubmed]
An effect of androgens on the length of the poly(A)-tail and alternative splicing cause size heterogeneity of the messenger ribonucleic acids encoding cystatin-related protein. Vercaeren, I., Winderickx, J., Devos, A., Peeters, B., Heyns, W. Endocrinology (1993) [Pubmed]
Structure of rat genes encoding androgen-regulated cystatin-related proteins (CRPs): a new member of the cystatin superfamily. Devos, A., De Clercq, N., Vercaeren, I., Heyns, W., Rombauts, W., Peeters, B. Gene (1993) [Pubmed]

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