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MeSH Review

5' Flanking Region

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Disease relevance of 5' Flanking Region


Psychiatry related information on 5' Flanking Region


High impact information on 5' Flanking Region


Chemical compound and disease context of 5' Flanking Region


Biological context of 5' Flanking Region


Anatomical context of 5' Flanking Region


Associations of 5' Flanking Region with chemical compounds


Gene context of 5' Flanking Region


Analytical, diagnostic and therapeutic context of 5' Flanking Region


  1. Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer. Denison, M.S., Fisher, J.M., Whitlock, J.P. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  2. Tumors in hepatobiliary tract and pancreatic islet tissues of transgenic mice harboring gastrin simian virus 40 large tumor antigen fusion gene. Montag, A.G., Oka, T., Baek, K.H., Choi, C.S., Jay, G., Agarwal, K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. Lewis, E.J., Harrington, C.A., Chikaraishi, D.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Obesity-linked regulation of the adipsin gene promoter in transgenic mice. Platt, K.A., Min, H.Y., Ross, S.R., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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  6. Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. Kim, S.J., Young, L.J., Gonen, D., Veenstra-VanderWeele, J., Courchesne, R., Courchesne, E., Lord, C., Leventhal, B.L., Cook, E.H., Insel, T.R. Mol. Psychiatry (2002) [Pubmed]
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  8. Unstable insertion in the 5' flanking region of the cystatin B gene is the most common mutation in progressive myoclonus epilepsy type 1, EPM1. Lafrenière, R.G., Rochefort, D.L., Chrétien, N., Rommens, J.M., Cochius, J.I., Kälviäinen, R., Nousiainen, U., Patry, G., Farrell, K., Söderfeldt, B., Federico, A., Hale, B.R., Cossio, O.H., Sørensen, T., Pouliot, M.A., Kmiec, T., Uldall, P., Janszky, J., Pranzatelli, M.R., Andermann, F., Andermann, E., Rouleau, G.A. Nat. Genet. (1997) [Pubmed]
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  12. Isolation and characterization of a functional murine interferon alpha gene which is not expressed in fibroblasts upon virus induction. Navarro, S., Dion, M., Vodjdani, G., Berlot-Picard, F., Doly, J. J. Gen. Virol. (1989) [Pubmed]
  13. Genetic alterations in the development of mammary and prostate cancer in the C3(1)/Tag transgenic mouse model. Yoshidome, K., Shibata, M.A., Maroulakou, I.G., Liu, M.L., Jorcyk, C.L., Gold, L.G., Welch, V.N., Green, J.E. Int. J. Oncol. (1998) [Pubmed]
  14. The thyrotropin-releasing hormone gene 1998: cloning, characterization, and transcriptional regulation in the central nervous system, heart, and testis. Wilber, J.F., Xu, A.H. Thyroid (1998) [Pubmed]
  15. The actin gene promoter-driven bar as a dominant selectable marker for nuclear transformation of Dunaliella salina. Jiang, G.Z., Lü, Y.M., Niu, X.L., Xue, L.X. Yi Chuan Xue Bao (2005) [Pubmed]
  16. Multiple mRNAs are generated from the chicken lysozyme gene. Grez, M., Land, H., Giesecke, K., Schütz, G., Jung, A., Sippel, A.E. Cell (1981) [Pubmed]
  17. Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes. Fujita, T., Shibuya, H., Ohashi, T., Yamanishi, K., Taniguchi, T. Cell (1986) [Pubmed]
  18. The primary structure of the human epsilon-globin gene. Baralle, F.E., Shoulders, C.C., Proudfoot, N.J. Cell (1980) [Pubmed]
  19. A distant enhancer element is required for polymerase III transcription of a U6 RNA gene. Bark, C., Weller, P., Zabielski, J., Janson, L., Pettersson, U. Nature (1987) [Pubmed]
  20. Deletion mapping of the inducible promoter of human IFN-beta gene. Tavernier, J., Gheysen, D., Duerinck, F., Van der Heyden, J., Fiers, W. Nature (1983) [Pubmed]
  21. Cell-specific expression of a transfected human alpha 1-antitrypsin gene. Ciliberto, G., Dente, L., Cortese, R. Cell (1985) [Pubmed]
  22. A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. Durand, D.B., Bush, M.R., Morgan, J.G., Weiss, A., Crabtree, G.R. J. Exp. Med. (1987) [Pubmed]
  23. Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines. Chen, E.H., Johnson, E.E., Vetter, S.M., Mitchell, B.S. J. Clin. Invest. (1995) [Pubmed]
  24. Some neuronal cell populations express human dopamine beta-hydroxylase-lacZ transgenes transiently during embryonic development. Kapur, R.P., Hoyle, G.W., Mercer, E.H., Brinster, R.L., Palmiter, R.D. Neuron (1991) [Pubmed]
  25. Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene. De Simone, V., Ciliberto, G., Hardon, E., Paonessa, G., Palla, F., Lundberg, L., Cortese, R. EMBO J. (1987) [Pubmed]
  26. An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Klein-Hitpass, L., Schorpp, M., Wagner, U., Ryffel, G.U. Cell (1986) [Pubmed]
  27. Functional analysis of the human vascular cell adhesion molecule 1 promoter. Neish, A.S., Williams, A.J., Palmer, H.J., Whitley, M.Z., Collins, T. J. Exp. Med. (1992) [Pubmed]
  28. Prostaglandins regulate the synthesis and secretion of the atrial natriuretic peptide. Gardner, D.G., Schultz, H.D. J. Clin. Invest. (1990) [Pubmed]
  29. Isolation and characterization of the mouse acetylcholine receptor delta subunit gene: identification of a 148-bp cis-acting region that confers myotube-specific expression. Baldwin, T.J., Burden, S.J. J. Cell Biol. (1988) [Pubmed]
  30. High-level tuber expression and sucrose inducibility of a potato Sus4 sucrose synthase gene require 5' and 3' flanking sequences and the leader intron. Fu, H., Kim, S.Y., Park, W.D. Plant Cell (1995) [Pubmed]
  31. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Fraser, J.D., Irving, B.A., Crabtree, G.R., Weiss, A. Science (1991) [Pubmed]
  32. Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. Messer, G., Spengler, U., Jung, M.C., Honold, G., Blömer, K., Pape, G.R., Riethmüller, G., Weiss, E.H. J. Exp. Med. (1991) [Pubmed]
  33. Expression of the Arabidopsis HMG2 gene, encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase, is restricted to meristematic and floral tissues. Enjuto, M., Lumbreras, V., Marín, C., Boronat, A. Plant Cell (1995) [Pubmed]
  34. The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters. Sugimoto, M., Oohashi, T., Ninomiya, Y. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  35. Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage. Tsumaki, N., Kimura, T., Matsui, Y., Nakata, K., Ochi, T. J. Cell Biol. (1996) [Pubmed]
  36. A plasmacytoma-specific factor binds the c-myc promoter region. Kakkis, E., Calame, K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  37. Identification of an inducible regulator of c-myb expression during T-cell activation. Phan, S.C., Feeley, B., Withers, D., Boxer, L.M. Mol. Cell. Biol. (1996) [Pubmed]
  38. Tissue-specific and developmentally regulated expression of a chimeric actin-globin gene in transgenic mice. Shani, M. Mol. Cell. Biol. (1986) [Pubmed]
  39. Molecular features of a new human lymphoma cell line carrying both BCL2 and BCL6 gene rearrangements. Yonetani, N., Akasaka, T., Akasaka, H., Ohno, H., Okuma, M., Miura, I., Takahashi, N., Miyanishi, S., Okumura, A., Muramatsu, M., Fukuhara, S. Oncogene (1998) [Pubmed]
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