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Gene Review:

Adam34 - a disintegrin and metallopeptidase domain 34

Mus musculus

Synonyms: testase 4

Brachvogel, B. et al.

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High impact information on Adam34

Reverse transcription-polymerase chain reaction showed a strong expression of testase 4 in the adult testis, but not in any other organ or embryonic stage tested [1].
These data indicate a correlation between testase 4 expression and spermatogenesis and/or fertilization [1].
The predicted protein sequence reveals highest homology to the testase-subgroup, composed of ADAM 24, ADAM 25 and ADAM 26 and is therefore called testase 4 [1].

Analytical, diagnostic and therapeutic context of Adam34

Careful characterization by in situ hybridization confirmed specific expression of testase 4 in maturing sperm cells of 6-week-old mice, whereas no specific hybridization pattern was detectable in testes of 2.5-week-old mice [1].

References

Molecular cloning and expression analysis of a novel member of the Disintegrin and Metalloprotease-Domain (ADAM) family. Brachvogel, B., Reichenberg, D., Beyer, S., Jehn, B., von der Mark, K., Bielke, W. Gene (2002) [Pubmed]

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