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MeSH Review


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Disease relevance of Spermatogenesis


Psychiatry related information on Spermatogenesis

  • There was a second period of Leydig cell secretory activity and increasing and peak plasma testosterone values in late winter/early summer which may be associated with copulation or the initiation of a new cycle of spermatogenesis [6].

High impact information on Spermatogenesis


Chemical compound and disease context of Spermatogenesis


Biological context of Spermatogenesis


Anatomical context of Spermatogenesis


Associations of Spermatogenesis with chemical compounds


Gene context of Spermatogenesis

  • Ccna1-/- males were sterile due to a block of spermatogenesis before the first meiotic division, whereas females were normal [30].
  • To investigate the role of Camk4 in spermatogenesis, we have generated mice with a targeted deletion of the gene Camk4 [22].
  • Motoneuron survival and spermiogenesis are severely compromised in the wobbler mouse, indicating that Vps54 has an essential role in these processes [7].
  • Expression of the X-inactivation-associated gene XIST during spermatogenesis [31].
  • Male Nhlh2-/- mice are microphallic, hypogonadal and infertile with alterations in circulating gonadotropins, a defect in spermatogenesis and a loss of instinctual male sexual behaviour [32].

Analytical, diagnostic and therapeutic context of Spermatogenesis


  1. Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Xu, X., Toselli, P.A., Russell, L.D., Seldin, D.C. Nat. Genet. (1999) [Pubmed]
  2. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Mazeyrat, S., Saut, N., Grigoriev, V., Mahadevaiah, S.K., Ojarikre, O.A., Rattigan A, n.u.l.l., Bishop, C., Eicher, E.M., Mitchell, M.J., Burgoyne, P.S. Nat. Genet. (2001) [Pubmed]
  3. A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B. Bashir, R., Britton, S., Strachan, T., Keers, S., Vafiadaki, E., Lako, M., Richard, I., Marchand, S., Bourg, N., Argov, Z., Sadeh, M., Mahjneh, I., Marconi, G., Passos-Bueno, M.R., Moreira, E.d.e. .S., Zatz, M., Beckmann, J.S., Bushby, K. Nat. Genet. (1998) [Pubmed]
  4. The pituitary-testicular axis in men with chronic renal failure. Holdsworth, S., Atkins, R.C., de Kretser, D.M. N. Engl. J. Med. (1977) [Pubmed]
  5. Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Toscani, A., Mettus, R.V., Coupland, R., Simpkins, H., Litvin, J., Orth, J., Hatton, K.S., Reddy, E.P. Nature (1997) [Pubmed]
  6. Seasonal changes in plasma testosterone concentrations and Leydig cell and accessory gland activity in the Cape horseshoe bat (Rhinolophus capensis). Bernard, R.T. J. Reprod. Fertil. (1986) [Pubmed]
  7. Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse. Schmitt-John, T., Drepper, C., Mussmann, A., Hahn, P., Kuhlmann, M., Thiel, C., Hafner, M., Lengeling, A., Heimann, P., Jones, J.M., Meisler, M.H., Jockusch, H. Nat. Genet. (2005) [Pubmed]
  8. Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nakamura, T., Yao, R., Ogawa, T., Suzuki, T., Ito, C., Tsunekawa, N., Inoue, K., Ajima, R., Miyasaka, T., Yoshida, Y., Ogura, A., Toshimori, K., Noce, T., Yamamoto, T., Noda, T. Nat. Genet. (2004) [Pubmed]
  9. Essential role of Plzf in maintenance of spermatogonial stem cells. Costoya, J.A., Hobbs, R.M., Barna, M., Cattoretti, G., Manova, K., Sukhwani, M., Orwig, K.E., Wolgemuth, D.J., Pandolfi, P.P. Nat. Genet. (2004) [Pubmed]
  10. The mouse X chromosome is enriched for sex-biased genes not subject to selection by meiotic sex chromosome inactivation. Khil, P.P., Smirnova, N.A., Romanienko, P.J., Camerini-Otero, R.D. Nat. Genet. (2004) [Pubmed]
  11. Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice. Calvin, H.I., Medvedovsky, C., Worgul, B.V. Science (1986) [Pubmed]
  12. "Viable motheaten," a new allele at the motheaten locus. I. Pathology. Shultz, L.D., Coman, D.R., Bailey, C.L., Beamer, W.G., Sidman, C.L. Am. J. Pathol. (1984) [Pubmed]
  13. Klinefelter syndrome. Smyth, C.M., Bremner, W.J. Arch. Intern. Med. (1998) [Pubmed]
  14. Estrogen-induced galactorrhea in man. Draznin, B., Maman, A. Arch. Intern. Med. (1979) [Pubmed]
  15. HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity. Yamamoto, H., Ochiya, T., Tamamushi, S., Toriyama-Baba, H., Takahama, Y., Hirai, K., Sasaki, H., Sakamoto, H., Saito, I., Iwamoto, T., Kakizoe, T., Terada, M. Oncogene (2002) [Pubmed]
  16. A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells. Zhong, J., Peters, A.H., Lee, K., Braun, R.E. Nat. Genet. (1999) [Pubmed]
  17. Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene. McCarrey, J.R., Thomas, K. Nature (1987) [Pubmed]
  18. Preferential germline mutation of the paternal allele in retinoblastoma. Zhu, X.P., Dunn, J.M., Phillips, R.A., Goddard, A.D., Paton, K.E., Becker, A., Gallie, B.L. Nature (1989) [Pubmed]
  19. Parthenogenetic activation of oocytes in c-mos-deficient mice. Hashimoto, N., Watanabe, N., Furuta, Y., Tamemoto, H., Sagata, N., Yokoyama, M., Okazaki, K., Nagayoshi, M., Takeda, N., Ikawa, Y. Nature (1994) [Pubmed]
  20. A mouse homeo box gene is expressed in spermatocytes and embryos. Rubin, M.R., Toth, L.E., Patel, M.D., D'Eustachio, P., Nguyen-Huu, M.C. Science (1986) [Pubmed]
  21. Gamete-specific methylation correlates with imprinting of the murine Xist gene. Ariel, M., Robinson, E., McCarrey, J.R., Cedar, H. Nat. Genet. (1995) [Pubmed]
  22. Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Wu, J.Y., Ribar, T.J., Cummings, D.E., Burton, K.A., McKnight, G.S., Means, A.R. Nat. Genet. (2000) [Pubmed]
  23. Normal spermatozoa from androgen-resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis. Lyon, M.F., Glenister, P.H., Lamoreux, M.L. Nature (1975) [Pubmed]
  24. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Meng, X., Lindahl, M., Hyvönen, M.E., Parvinen, M., de Rooij, D.G., Hess, M.W., Raatikainen-Ahokas, A., Sainio, K., Rauvala, H., Lakso, M., Pichel, J.G., Westphal, H., Saarma, M., Sariola, H. Science (2000) [Pubmed]
  25. Androgen insensitivity as a cause of infertility in otherwise normal men. Aiman, J., Griffin, J.E., Gazak, J.M., Wilson, J.D., MacDonald, P.C. N. Engl. J. Med. (1979) [Pubmed]
  26. Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotropin-releasing hormone agonist in normal men: an approach toward the development of a male contraceptive. Linde, R., Doelle, G.C., Alexander, N., Kirchner, F., Vale, W., Rivier, J., Rabin, D. N. Engl. J. Med. (1981) [Pubmed]
  27. Synergistic interaction of testosterone and oestradiol inhibits spermatogenesis in rats. Ewing, L.L., Desjardins, C., Irby, D.C., Robaire, B. Nature (1977) [Pubmed]
  28. Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs. Colledge, W.H., Carlton, M.B., Udy, G.B., Evans, M.J. Nature (1994) [Pubmed]
  29. Estrogen and spermatogenesis. O'Donnell, L., Robertson, K.M., Jones, M.E., Simpson, E.R. Endocr. Rev. (2001) [Pubmed]
  30. Cyclin A1 is required for meiosis in the male mouse. Liu, D., Matzuk, M.M., Sung, W.K., Guo, Q., Wang, P., Wolgemuth, D.J. Nat. Genet. (1998) [Pubmed]
  31. Expression of the X-inactivation-associated gene XIST during spermatogenesis. Salido, E.C., Yen, P.H., Mohandas, T.K., Shapiro, L.J. Nat. Genet. (1992) [Pubmed]
  32. Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Good, D.J., Porter, F.D., Mahon, K.A., Parlow, A.F., Westphal, H., Kirsch, I.R. Nat. Genet. (1997) [Pubmed]
  33. Localization of protamine 1 mRNA in different stages of the cycle of the rat seminiferous epithelium. Mali, P., Sandberg, M., Vuorio, E., Yelick, P.C., Hecht, N.B., Parvinen, M. J. Cell Biol. (1988) [Pubmed]
  34. Proenkephalin products are stored in the sperm acrosome and may function in fertilization. Kew, D., Muffly, K.E., Kilpatrick, D.L. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  35. Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese eel (Anguilla japonica). Miura, T., Yamauchi, K., Takahashi, H., Nagahama, Y. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  36. PCR analysis of the Y chromosome long arm in azoospermic patients: evidence for a second locus required for spermatogenesis. Kobayashi, K., Mizuno, K., Hida, A., Komaki, R., Tomita, K., Matsushita, I., Namiki, M., Iwamoto, T., Tamura, S., Minowada, S. Hum. Mol. Genet. (1995) [Pubmed]
  37. Analysis of male sterile mutations in the mouse using haploid stage expressed cDNA probes. Dudley, K., Potter, J., Lyon, M.F., Willison, K.R. Nucleic Acids Res. (1984) [Pubmed]
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