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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nfyb  -  nuclear transcription factor-Y beta

Rattus norvegicus

Synonyms: CAAT box DNA-binding protein subunit B, CBF-B, CBFB, CCAAT-binding transcription factor subunit B, NF-YB, ...
 
 
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High impact information on Nfyb

  • Addition of the ligand 1alpha,25-dihydroxyvitamin D3 or the presence of other transcription factors, such as YY1 and Runx/Cbfa (core-binding factor alpha), which also bind to sequences partially overlapping or near the VDRE, is not sufficient to render the VDRE accessible [1].
  • These two proteins share an identical amino acid sequence except for a 47-residue-insertion in AlF-C1, and are members of a gene family including heterogeneous nuclear ribonucleoprotein (hnRNP) and CCAAT-binding factor subunit A (CBF-A) genes [2].
  • This region-dependent transcription in cardiac myocytes transfected with antisense cDNAs encoding NF-YA and NF-YB was decreased to approximately 50% of that seen in cells transfected with the same sense cDNAs [3].
  • The bound proteins were analyzed by 2D gel electrophoresis, and the following five hnRNP A/B-type proteins were identified by tandem mass spectrometry: DBP40/CBF-A (CArG binding factor A), a minor hnRNP A2 variant and three minor hnRNP A3 (mBx) variants [4].
 

Other interactions of Nfyb

  • This region specifically bound to nuclear proteins extracted from rat hearts, and gel-shift assays using competitive oligonucleotides, antibodies and recombinant proteins showed that this region binds to the NF-YA and NF-YB, members of the CCAAT-binding nuclear protein family [3].

References

  1. Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Paredes, R., Gutiérrez, J., Gutierrez, S., Allison, L., Puchi, M., Imschenetzky, M., van Wijnen, A., Lian, J., Stein, G., Stein, J., Montecino, M. Biochem. J. (2002) [Pubmed]
  2. A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter. Yabuki, T., Miyagi, S., Ueda, H., Saitoh, Y., Tsutsumi, K. Gene (2001) [Pubmed]
  3. Involvement of NF-Y in transcriptional regulation of the phospholamban gene. Yabuki, M., Toyofuku, T., Otsu, K., Nishida, M., Kuzuya, T., Hori, M., Tada, M. Eur. J. Biochem. (1998) [Pubmed]
  4. Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins. Percipalle, P., Jonsson, A., Nashchekin, D., Karlsson, C., Bergman, T., Guialis, A., Daneholt, B. Nucleic Acids Res. (2002) [Pubmed]
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