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Gene Review

res2  -  MBF transcription factor complex subunit Res2

Schizosaccharomyces pombe 972h-

Synonyms: mcs1, pct1
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High impact information on res2

  • We suggest that S-phase transcription is controlled by both activation and repression, and that res2p represses transcription in G2 of the cell cycle as a part of the DSC1 complex [1].
  • The rep1 null mutant fails to induce the res2+ gene, a newly identified res1+ homolog cooperating with Cdc10 and acting for the onset of mitotic and premeiotic DNA synthesis, as well as for meiotic division [2].
  • Eleven of 17 mutants that suppress this phenotype define a single complementation group, mcs1 [3].
  • Furthermore, knockout of the pct1(+) gene encoding a choline phosphate cytidyltransferase rescued the gdi1-i11 mutation [4].


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