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Gene Review

res1  -  MBF transcription factor complex subunit Res1

Schizosaccharomyces pombe 972h-

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High impact information on res1

  • We find that transcription of cdc18, together with the transcription of other cdc10p/res1p targets, is first initiated as cells enter mitosis and continues even in cells arrested in mitosis with highly condensed chromatin [1].
  • This is composed of at least the products of the cdc10 and sct1/res1 genes, and binds to the promoters of genes whose expression increases prior to S phase [2].
  • The res1+ gene specifies a 72 kDa protein with two copies of the cdc10/SWI6 motif [3].

Biological context of res1


  1. Cdc18 transcription and proteolysis couple S phase to passage through mitosis. Baum, B., Nishitani, H., Yanow, S., Nurse, P. EMBO J. (1998) [Pubmed]
  2. The activity of S.pombe DSC-1-like factor is cell cycle regulated and dependent on the activity of p34cdc2. Reymond, A., Marks, J., Simanis, V. EMBO J. (1993) [Pubmed]
  3. A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products. Tanaka, K., Okazaki, K., Okazaki, N., Ueda, T., Sugiyama, A., Nojima, H., Okayama, H. EMBO J. (1992) [Pubmed]
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