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Gene Review

rad25  -  14-3-3 protein Rad25

Schizosaccharomyces pombe 972h-

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High impact information on SPAC17A2.13c

  • In addition, S. pombe rad24 null mutants, and to a lesser extent rad25 null mutants, enter mitosis prematurely, which indicates that 14-3-3 proteins have a role in determining the timing of mitosis [1].

Biological context of SPAC17A2.13c

  • In Schizosaccharomyces pombe, rad24 and rad25 have been identified to be homologous to mammalian 14-3-3 genes and found to be involved in many cellular events, including checkpoint and meiosis [2].


  1. 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Ford, J.C., al-Khodairy, F., Fotou, E., Sheldrick, K.S., Griffiths, D.J., Carr, A.M. Science (1994) [Pubmed]
  2. The 14-3-3 proteins Rad24 and Rad25 negatively regulate Byr2 by affecting its localization in Schizosaccharomyces pombe. Ozoe, F., Kurokawa, R., Kobayashi, Y., Jeong, H.T., Tanaka, K., Sen, K., Nakagawa, T., Matsuda, H., Kawamukai, M. Mol. Cell. Biol. (2002) [Pubmed]
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