Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

med13 - mediator complex subunit Srb9

Schizosaccharomyces pombe 972h-

Synonyms: spTrap240, srb9

Spahr, H. et al., Samuelsen, C.O. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SPAC589.02c

Importantly, Mediator containing the spSrb8/spTrap240/spSrb10/spSrb11 subunits is isolated only in free form, devoid of RNA polymerase II [1].
We find that spSrb8/spTrap240/spSrb10/spSrb11 containing Mediator repress basal transcription, whereas Mediator lacking these subunits has a stimulatory effect on transcription [2].

References

TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Samuelsen, C.O., Baraznenok, V., Khorosjutina, O., Spahr, H., Kieselbach, T., Holmberg, S., Gustafsson, C.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro. Spahr, H., Khorosjutina, O., Baraznenok, V., Linder, T., Samuelsen, C.O., Hermand, D., Mäkela, T.P., Holmberg, S., Gustafsson, C.M. J. Biol. Chem. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share