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Gene Review

iki3  -  elongator subunit Iki3 (predicted)

Schizosaccharomyces pombe 972h-

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Disease relevance of SPBC36.07


High impact information on SPBC36.07


Biological context of SPBC36.07


Anatomical context of SPBC36.07

  • The distribution of RNA polymerase II and morphological details that could be observed in the extra-nucleolar region of cryofixed cells provided cytological evidence of a peripheral region extending along the nuclear envelope that could correspond to heterochromatin in higher eukaryotes [12].

Associations of SPBC36.07 with chemical compounds


Other interactions of SPBC36.07

  • To gain an insight into the roles of subunit 3, the eukaryotic homologue of alpha, temperature-sensitive mutants of the fission yeast, Schizosaccharomyces pombe, have been isolated after transformation of the mutagenized rpb3 gene encoding mutant subunit 3 of RNA polymerase II [15].
  • Importantly, Mediator containing the spSrb8/spTrap240/spSrb10/spSrb11 subunits is isolated only in free form, devoid of RNA polymerase II [16].
  • Cyclin-dependent kinase 9 (Cdk9) of fission yeast is an essential ortholog of metazoan positive transcription elongation factor b (P-TEFb), which is proposed to coordinate capping and elongation of RNA polymerase II (Pol II) transcripts [17].
  • A notable exception is a 19-bp block, centered 36 nucleotides upstream from the transcriptional start site, in which the two loci match in 15 positions; this motif may represent an RNA polymerase II upstream regulatory element, because related sequences are found preceding fission yeast U1, U2, U4, and U5 snRNA genes [18].
  • In this report, characterization of XPB mutants indicates that its helicase activity is not used for RNA polymerase II promoter opening, which is instead driven by its ATPase activity [19].

Analytical, diagnostic and therapeutic context of SPBC36.07


  1. An RNA polymerase II complex containing capping enzymes and viral oncoproteins. Cabrejos, M.E., Maldonado, E. IUBMB Life (2000) [Pubmed]
  2. Mediator of transcriptional regulation. Myers, L.C., Kornberg, R.D. Annu. Rev. Biochem. (2000) [Pubmed]
  3. RNA polymerase II initiation factor interactions and transcription start site selection. Li, Y., Flanagan, P.M., Tschochner, H., Kornberg, R.D. Science (1994) [Pubmed]
  4. RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing. Djupedal, I., Portoso, M., Spåhr, H., Bonilla, C., Gustafsson, C.M., Allshire, R.C., Ekwall, K. Genes Dev. (2005) [Pubmed]
  5. The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7. Akoulitchev, S., Reinberg, D. Genes Dev. (1998) [Pubmed]
  6. A role for chromatin remodeling in transcriptional termination by RNA polymerase II. Alén, C., Kent, N.A., Jones, H.S., O'Sullivan, J., Aranda, A., Proudfoot, N.J. Mol. Cell (2002) [Pubmed]
  7. Recruitment of P-TEFb (Cdk9-Pch1) to chromatin by the cap-methyl transferase Pcm1 in fission yeast. Guiguen, A., Soutourina, J., Dewez, M., Tafforeau, L., Dieu, M., Raes, M., Vandenhaute, J., Werner, M., Hermand, D. EMBO J. (2007) [Pubmed]
  8. A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thaliana. Umeda, M., Bhalerao, R.P., Schell, J., Uchimiya, H., Koncz, C. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Kizer, K.O., Phatnani, H.P., Shibata, Y., Hall, H., Greenleaf, A.L., Strahl, B.D. Mol. Cell. Biol. (2005) [Pubmed]
  10. Functional organization of two large subunits of the fission yeast Schizosaccharomyces pombe RNA polymerase II. Location of the catalytic sites. Wlassoff, W.A., Kimura, M., Ishihama, A. J. Biol. Chem. (1999) [Pubmed]
  11. Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis. Pei, Y., Shuman, S. J. Biol. Chem. (2003) [Pubmed]
  12. Functional compartmentalization of the nucleus in the budding yeast Saccharomyces cerevisiae. Léger-Silvestre, I., Trumtel, S., Noaillac-Depeyre, J., Gas, N. Chromosoma (1999) [Pubmed]
  13. Purification and characterization of yeast RNA polymerase II general initiation factor g. Henry, N.L., Sayre, M.H., Kornberg, R.D. J. Biol. Chem. (1992) [Pubmed]
  14. Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Morris, S.A., Shibata, Y., Noma, K., Tsukamoto, Y., Warren, E., Temple, B., Grewal, S.I., Strahl, B.D. Eukaryotic Cell (2005) [Pubmed]
  15. Isolation of thermolabile mutant RNA polymerase II from fission yeast Schizosaccharomyces pombe with mutations in the subunit 3 gene. Azuma, Y., Yasui, K., Yamagishi, M., Ishihama, A. J. Biochem. (1995) [Pubmed]
  16. TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Samuelsen, C.O., Baraznenok, V., Khorosjutina, O., Spahr, H., Kieselbach, T., Holmberg, S., Gustafsson, C.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Pei, Y., Du, H., Singer, J., Stamour, C., Granitto, S., Shuman, S., Fisher, R.P. Mol. Cell. Biol. (2006) [Pubmed]
  18. The two similarly expressed genes encoding U3 snRNA in Schizosaccharomyces pombe lack introns. Selinger, D.A., Porter, G.L., Brennwald, P.J., Wise, J.A. Mol. Biol. Evol. (1992) [Pubmed]
  19. TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape. Lin, Y.C., Choi, W.S., Gralla, J.D. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  20. Cloning and sequence determination of the Schizosaccharomyces pombe rpb1 gene encoding the largest subunit of RNA polymerase II. Azuma, Y., Yamagishi, M., Ueshima, R., Ishihama, A. Nucleic Acids Res. (1991) [Pubmed]
  21. The fission yeast Rpb4 subunit of RNA polymerase II plays a specialized role in cell separation. Sharma, N., Marguerat, S., Mehta, S., Watt, S., B??hler, J. Mol. Genet. Genomics (2006) [Pubmed]
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