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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

spp42  -  U5 snRNP complex subunit Spp42

Schizosaccharomyces pombe 972h-

 
 
 
 
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High impact information on SPAC4F8.12c

  • Mutations in both suppressor genes suppress the growth and the pre-mRNA splicing defect of prp4-73(ts) at the restrictive temperature (36 degrees ). spp41 and spp42 are synthetically lethal with each other in the presence of prp4-73(ts), indicating a functional relationship between spp41 and spp42 [1].
 

Analytical, diagnostic and therapeutic context of SPAC4F8.12c

  • Based on our mapping data we isolated spp42 by screening PCR fragments for functional complementation of the prp4-73(ts) mutant at the restrictive temperature. spp42 encodes a large protein (p275), which is the homologue of Prp8p [1].

References

  1. spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p. Schmidt, H., Richert, K., Drakas, R.A., Käufer, N.F. Genetics (1999) [Pubmed]
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