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Gene Review

ryh1  -  GTPase Ryh1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on ryh1

  • The other isolate, named ryh1, and a fourth homolog, ypt2, have been characterized by Gallwitz and co-workers [1].
  • The temperature-sensitive phenotype of ryh1 null mutants is complemented by the human rab6 cDNA expressed either under transcriptional control of the S.pombe adh or the SV40 early promoter [2].
  • The ryh1 gene is interrupted by three introns. ryh1 null mutants are viable but unable to grow at temperatures greater than 35.5 degrees C. Invertase of ryh1- cells is properly secreted but has a faster electrophoretic mobility compared to that of wild-type cells [2].
  • Interestingly, ryh1+ gene deletion was synthetically lethal with ypt3-i5 mutation [3].

References

 
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