Disease relevance of hydC

• In Wolinella succinogenes, the hydC gene, homologous to hupC, has been shown to encode a low potential cytochrome b which mediates electron transfer from H2 to the quinone pool of the bacterial membrane [1].

High impact information on hydC

• The DeltahydABC mutant was complemented with hydABC operons modified by artificial stop codons in hydA (StopA) or at the 5'-end of hydC (StopC) [2].
• The amino acid sequences derived from hydA, hydB and hydC were similar to those of the membrane Ni-hydrogenases of seven other bacteria [3].
• Separated by an intergene region of 69 nucleotides, hydC was followed by at least two more open reading frames of unknown function [3].

Biological context of hydC

• The three genes were arranged in the order hydA, hydB, hydC, with the transcription start site in front of hydA, and were present only once on the genome [3].

References