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Gene Review: 

Ddr1  -  discoidin domain receptor tyrosine kinase 1

Rattus norvegicus

Synonyms: CD167 antigen-like family member A, Cak, Cell adhesion kinase, Discoidin receptor tyrosine kinase, Drd1, ...
 
 
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High impact information on Ddr1

  • Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain [1].
  • Radiation induction of the receptor tyrosine kinase gene Ptk-3 in normal rat astrocytes [2].
  • Cloning studies indicated the presence of at least two Ptk-3 mRNA transcripts, which are probably the result of an alternative splicing mechanism [2].
  • The protein encoded by Ptk-3 is a member of a novel class of receptor tyrosine kinases whose extracellular domain contains regions of homology with coagulation factors V and VIII and complement component C1 [2].
 

Analytical, diagnostic and therapeutic context of Ddr1

  • Northern blot analysis revealed that the expression of Ptk-3 was increased in rat astrocytes by 0.5 h after exposure to 10 Gy and remained at the same elevated level for at least 24 h [2].

References

  1. Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain. Sánchez, M.P., Tapley, P., Saini, S.S., He, B., Pulido, D., Barbacid, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Radiation induction of the receptor tyrosine kinase gene Ptk-3 in normal rat astrocytes. Sakuma, S., Saya, H., Ijichi, A., Tofilon, P.J. Radiat. Res. (1995) [Pubmed]
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