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Gene Review:

SUMF2 - sulfatase modifying factor 2

Homo sapiens

Synonyms: C-alpha-formylglycine-generating enzyme 2, DKFZp566I1024, PSEC0171, Sulfatase-modifying factor 2, UNQ1968/PRO4500

Landgrebe, J. et al., Zito, E. et al.

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High impact information on SUMF2

We present evidence that SUMF2 colocalizes with SUMF1 within the endoplasmic reticulum and that the two proteins form heterodimers [1].

Biological context of SUMF2

The genomes of vertebrates including mouse, man and pufferfish contain a sulfatase modifying factor 2 (SUMF2) gene encoding an FGE paralog of unknown function [2].

Other interactions of SUMF2

SUMF2 evolved from a single exon SUMF1 gene as found in diptera prior to divergent intron acquisition [2].

References

Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito, E., Fraldi, A., Pepe, S., Annunziata, I., Kobinger, G., Di Natale, P., Ballabio, A., Cosma, M.P. EMBO Rep. (2005) [Pubmed]
The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes. Landgrebe, J., Dierks, T., Schmidt, B., von Figura, K. Gene (2003) [Pubmed]

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SUMF2	Bos taurus
SUMF2	Canis lupus familiaris
sumf2	Danio rerio
SUMF2	Gallus gallus
LOC715253	Macaca mulatta
Sumf2	Mus musculus
SUMF2	Pan troglodytes
Sumf2	Rattus norvegicus
sumf2	Xenopus (Silurana) tropicalis

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