Disease relevance of MTHFD1L

• Through the analysis we found one gene named DKFZp586G1517 that was upregulated in colon adenocarcinomas [1].

High impact information on MTHFD1L

• The gene product expressed in 293 cells was localized in mitochondria and processed at the predicted signal cleavage site, supporting the idea that DKFZp586G1517 is a novel mitochondrial C(1)-tetrahydrofolate synthetase (mtC(1)-THFS) [1].

Analytical, diagnostic and therapeutic context of MTHFD1L

• The full-length cDNA of the DKFZp586G1517 cloned by polymerase chain reaction (PCR) encodes a protein with 978 amino acids, which is homologous to the human cytosolic C(1)-tetrahydrofolate synthetase and contains a mitochondrial target signal at N-terminus [1].

References