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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TIMM10  -  translocase of inner mitochondrial...

Homo sapiens

Synonyms: Mitochondrial import inner membrane translocase subunit Tim10, TIM10, TIM10A
 
 
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High impact information on TIMM10

  • The first high-resolution structure of a mitochondrial translocase complex, the Tim9-Tim10 chaperone, is reported by Webb et al [1].
  • The import of polytopic membrane proteins into the mitochondrial inner membrane (IM) is facilitated by Tim9p/Tim10p and Tim8p/Tim13p protein complexes in the intermembrane space (IMS) [2].
  • Prothymosin alpha (PTMA), and translocase of inner mitochondrial membrane 10 (Tim10), two genes not previously implicated in RMS, showed reduced expression during differentiation [3].
 

Anatomical context of TIMM10

  • Marked differences in the expression of PTMA and Tim10 were observed during the differentiation of human primary skeletal muscle cells [3].
 

Other interactions of TIMM10

  • They are structurally related to Tim9 and Tim10, essential components of the import machinery for mitochondrial carrier proteins [4].

References

  1. Chaperoning through the mitochondrial intermembrane space. Wiedemann, N., Pfanner, N., Chacinska, A. Mol. Cell (2006) [Pubmed]
  2. The Tim9p/10p and Tim8p/13p Complexes Bind to Specific Sites on Tim23p during Mitochondrial Protein Import. Davis, A.J., Alder, N.N., Jensen, R.E., Johnson, A.E. Mol. Biol. Cell (2007) [Pubmed]
  3. Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays. Carey, K.A., Segal, D., Klein, R., Sanigorski, A., Walder, K., Collier, G.R., Cameron-Smith, D. Pathol. Int. (2006) [Pubmed]
  4. The role of the TIM8-13 complex in the import of Tim23 into mitochondria. Paschen, S.A., Rothbauer, U., Káldi, K., Bauer, M.F., Neupert, W., Brunner, M. EMBO J. (2000) [Pubmed]
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