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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TIMM13  -  translocase of inner mitochondrial...

Homo sapiens

Synonyms: Mitochondrial import inner membrane translocase subunit Tim13, TIM13, TIM13B, TIMM13A, TIMM13B, ...
 
 
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High impact information on TIMM13

  • TIMM8a partners with TIMM13 in the mitochondrial intermembrane space to form a 70 kDa complex and facilitates the import of the inner membrane substrate TIMM23 [1].
  • Protein expression studies indicate that DDP1 and TIMM13 show non-uniform expression in mammals, and expression is prominent in the large neurons in the brain, which is in agreement with the expression pattern of aralar1 [1].
  • The import of polytopic membrane proteins into the mitochondrial inner membrane (IM) is facilitated by Tim9p/Tim10p and Tim8p/Tim13p protein complexes in the intermembrane space (IMS) [2].
  • In addition, the partner protein Tim13 was found to be significantly reduced, suggesting that Tim13 requires the presence of DDP1 for its stabilization [3].
  • Tim8 and Tim13 of yeast belong to a family of evolutionary conserved zinc finger proteins that are organized in hetero-oligomeric complexes in the mitochondrial intermembrane space [4].
 

Biological context of TIMM13

  • The recently developed procedure of topoisomerase II-mediated DNA loop excision has been used to analyze the topological organization of a human genome fragment containing the gene encoding lamin B2 and the ppv1 gene [5].
 

Other interactions of TIMM13

  • The poly(A) signal of the human Lamin B2 gene was previously shown to lie 600 bp upstream of the cap site of a gene of unknown function (ppv 1) [6].

References

  1. The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex. Roesch, K., Hynds, P.J., Varga, R., Tranebjaerg, L., Koehler, C.M. Hum. Mol. Genet. (2004) [Pubmed]
  2. The Tim9p/10p and Tim8p/13p Complexes Bind to Specific Sites on Tim23p during Mitochondrial Protein Import. Davis, A.J., Alder, N.N., Jensen, R.E., Johnson, A.E. Mol. Biol. Cell (2007) [Pubmed]
  3. Clinical and molecular findings in a patient with a novel mutation in the deafness-dystonia peptide (DDP1) gene. Binder, J., Hofmann, S., Kreisel, S., Wöhrle, J.C., Bäzner, H., Krauss, J.K., Hennerici, M.G., Bauer, M.F. Brain (2003) [Pubmed]
  4. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. Rothbauer, U., Hofmann, S., Mühlenbein, N., Paschen, S.A., Gerbitz, K.D., Neupert, W., Brunner, M., Bauer, M.F. J. Biol. Chem. (2001) [Pubmed]
  5. DNA loop anchorage region colocalizes with the replication origin located downstream to the human gene encoding lamin B2. Lagarkova, M.A., Svetlova, E., Giacca, M., Falaschi, A., Razin, S.V. J. Cell. Biochem. (1998) [Pubmed]
  6. Transcription and polyadenylation in a short human intergenic region. Brackenridge, S., Ashe, H.L., Giacca, M., Proudfoot, N.J. Nucleic Acids Res. (1997) [Pubmed]
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