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Gene Review: 

p12  -  p12 protein

Pelargonium flower break virus

 
 
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High impact information on p12

  • Some constraints limiting viral heterogeneity could be inferred from sequence analyses, such as the conservation of the amino acid sequences of p7 and of the shell domain of the CP, the maintenance of a leucine zipper motif in p12, and the preservation of a particular folding in the 3' UTR [1].
  • The p12 ORF is in-frame with the p86 ORF and a double read-through protein of 99 kDa (p99) may be produced [2].
  • Interestingly, p12 presents a leucine zipper motif that has not been previously reported in related proteins [2].
  • Two small ORFs, located in the central part of the viral genome, encode polypeptides of 7 (p7) and 12 kDa (p12), respectively, which are very likely involved in virus movement [2].
  • Another ORF encoding a 12 kDa protein (p12) overlaps the p99 ORF.JINRV RNA treated with bacterial alkaline phosphatase and tobacco acid pyrophosphatase could not be ligated to an oligoribonucleotide using T4 RNA ligase, indicating that the 5' end of the viral RNA is uncapped [3].

References

  1. Insights into the selective pressures restricting Pelargonium flower break virus genome variability: Evidence for host adaptation. Rico, P., Ivars, P., Elena, S.F., Hernández, C. J. Virol. (2006) [Pubmed]
  2. Complete nucleotide sequence and genome organization of Pelargonium flower break virus. Rico, P., Hernández, C. Arch. Virol. (2004) [Pubmed]
  3. The nucleotide sequence and genome organization of Japanese iris necrotic ring virus, a new species in the genus Carmovirus. Takemoto, Y., Kanehira, T., Shinohara, M., Yamashita, S., Hibi, T. Arch. Virol. (2000) [Pubmed]
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