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Gene Review:

ompR - osmolarity response regulator

Bordetella pertussis Tohama I

Stenson, T.H. et al., Cróinín, T.O. et al.

Stenson, Allen, Al-Meer, Maskell, Peppler,

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Disease relevance of risA

Here, we show that mutation of B. pertussis risA does not affect Bvg-activated genes or proteins [1].

High impact information on risA

Deletion of the intact part of the B. pertussis risS gene does not affect the expression of risA-dependent, Bvg-repressed genes [1].
Mutation of risA also resulted in decreased bacterial invasion in a HeLa cell model [1].
Our analyses demonstrated that all four genes are repressed by the product of the bvgR locus and are activated by the product of the risA locus [2].

References

Bordetella pertussis risA, but not risS, is required for maximal expression of Bvg-repressed genes. Stenson, T.H., Allen, A.G., Al-Meer, J.A., Maskell, D., Peppler, M.S. Infect. Immun. (2005) [Pubmed]
Activation of the vrg6 promoter of Bordetella pertussis by RisA. Cróinín, T.O., Grippe, V.K., Merkel, T.J. J. Bacteriol. (2005) [Pubmed]

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