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Gene Review

MRX81  -  mental retardation, X-linked 81

Homo sapiens

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Disease relevance of MRX81


High impact information on MRX81

  • Tight linkage of MRX81 to DNA markers ALAS2, DXS991, and DXS7132 was observed with a maximum LOD score of 3.43 [1].
  • Haplotype construction delineates an MRX81 critical region of 8 cM, the smallest MRX pericentromeric interval so far described, between DXS1039 and DXS1216, and placing it in Xp11.2-Xq12 [1].


  1. Mapping of MRX81 in Xp11.2-Xq12 suggests the presence of a new gene involved in nonspecific X-linked mental retardation. Annunziata, I., Lanzara, C., Conte, I., Zullo, A., Ventruto, V., Rinaldi, M.M., D'Urso, M., Casari, G., Ciccodicola, A., Miano, M.G. Am. J. Med. Genet. A (2003) [Pubmed]
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