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Gene Review

dsh-2  -  Protein DSH-2

Caenorhabditis elegans

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High impact information on dsh-2

  • As in pop-1 mutants, dsh-2 hermaphrodites have Z1 and Z4 lineage defects indicative of defective PD polarity and are missing gonadal arms [1].
  • Asymmetric distribution of nuclear GFP::POP-1 in Z1 and Z4 daughter cells is reversed in dsh-2 mutants, with higher levels in distal than proximal daughters. dsh-2 and the frizzled receptor homolog lin-17 have a strong genetic interaction, suggesting that they act in a common pathway [1].


  1. DSH-2 regulates asymmetric cell division in the early C. elegans somatic gonad. Chang, W., Lloyd, C.E., Zarkower, D. Mech. Dev. (2005) [Pubmed]
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