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Gene Review

Dvl2  -  dishevelled 2, dsh homolog (Drosophila)

Mus musculus

Synonyms: DSH homolog 2, Dishevelled-2, Segment polarity protein dishevelled homolog DVL-2
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Disease relevance of Dvl2

  • Mice containing null mutations in Dvl2 present with 50% lethality in both inbred 129S6 and in a hybrid 129S6-NIH Black Swiss background because of severe cardiovascular outflow tract defects, including double outlet right ventricle, transposition of the great arteries and persistent truncus arteriosis [1].
  • Finally, 2-3% of Dvl2(-/-) embryos displayed thoracic spina bifida, while virtually all Dvl1/2 double mutant embryos displayed craniorachishisis, a completely open neural tube from the midbrain to the tail [1].

High impact information on Dvl2

  • Expression of these constructs results in stunted hair growth, a phenotype that has also been observed in transgenic mice expressing Wnt3 and Dvl2 (Millar et al. 1999) [2].
  • When Dvl-2 localization was altered using a C-terminal CAAX motif, Axin was also redistributed, suggesting a close association between the two proteins, a conclusion supported by co-immunoprecipitation data [3].
  • Expression of Pitx2 and plexin A2 was attenuated in Dvl2 null mutants, suggesting a defect in cardiac neural crest development during outflow tract formation [1].
  • The majority of the surviving Dvl2(-/-) mice were female, suggesting that penetrance was influenced by sex [1].
  • Thus, Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes [1].

Biological context of Dvl2


Anatomical context of Dvl2


Analytical, diagnostic and therapeutic context of Dvl2

  • To demonstrate functional conservation of Dsh family proteins, two mouse homologs of Drosophila Dsh, Dvl-1 and Dvl-2, were biochemically characterized in mouse and Drosophila cell culture systems [7].


  1. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Hamblet, N.S., Lijam, N., Ruiz-Lozano, P., Wang, J., Yang, Y., Luo, Z., Mei, L., Chien, K.R., Sussman, D.J., Wynshaw-Boris, A. Development (2002) [Pubmed]
  2. Plakoglobin suppresses epithelial proliferation and hair growth in vivo. Charpentier, E., Lavker, R.M., Acquista, E., Cowin, P. J. Cell Biol. (2000) [Pubmed]
  3. Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. Smalley, M.J., Sara, E., Paterson, H., Naylor, S., Cook, D., Jayatilake, H., Fryer, L.G., Hutchinson, L., Fry, M.J., Dale, T.C. EMBO J. (1999) [Pubmed]
  4. Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. Endo, Y., Wolf, V., Muraiso, K., Kamijo, K., Soon, L., Uren, A., Barshishat-Küpper, M., Rubin, J.S. J. Biol. Chem. (2005) [Pubmed]
  5. Stage-dependent Dishevelled-1 expression during mouse spermatogenesis suggests a role in regulating spermatid morphological changes. Ma, P., Wang, H., Guo, R., Ma, Q., Yu, Z., Jiang, Y., Ge, Y., Ma, J., Xue, S., Han, D. Mol. Reprod. Dev. (2006) [Pubmed]
  6. Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Na, J., Lykke-Andersen, K., Torres Padilla, M.E., Zernicka-Goetz, M. Dev. Biol. (2007) [Pubmed]
  7. Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. Lee, J.S., Ishimoto, A., Yanagawa, S. J. Biol. Chem. (1999) [Pubmed]
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