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Gene Review

DVL2  -  dishevelled segment polarity protein 2

Homo sapiens

Synonyms: DSH homolog 2, Dishevelled-2, Segment polarity protein dishevelled homolog DVL-2
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High impact information on DVL2

  • Knockdown of Dpr1 by RNA interference up-regulates endogenous Dvl2 protein [1].
  • Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta [2].
  • We also demonstrated that Wnt16b mediates its effect through the canonical Wnt pathway involving dishevelled-2, beta-catenin and survivin [3].
  • Because of their D category V-like phenotypes, the RHD(Arg229del) allele was dubbed DVL-1 and the RHD(Lys235del) allele DVL-2 [4].
  • We produced antibodies against human Dishevelled-2 and demonstrated that it is a phosphoprotein and can be detected in all cell lines and human embryonic tissues examined [5].

Biological context of DVL2

  • Like the other genes, Dvl2 is ubiquitously expressed throughout most of embryogenesis and is expressed in many adult organs [6].

Anatomical context of DVL2


Associations of DVL2 with chemical compounds


  1. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. Zhang, L., Gao, X., Wen, J., Ning, Y., Chen, Y.G. J. Biol. Chem. (2006) [Pubmed]
  2. Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. Smalley, M.J., Signoret, N., Robertson, D., Tilley, A., Hann, A., Ewan, K., Ding, Y., Paterson, H., Dale, T.C. J. Cell. Sci. (2005) [Pubmed]
  3. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Mazieres, J., You, L., He, B., Xu, Z., Lee, A.Y., Mikami, I., McCormick, F., Jablons, D.M. Oncogene (2005) [Pubmed]
  4. In-frame triplet deletions in RHD alter the D antigen phenotype. Flegel, W.A., Eicher, N.I., Doescher, A., Hustinx, H., Gowland, P., Mansouri Taleghani, B., Petershofen, E.K., Bauerfeind, U., Ernst, M., von Zabern, I., Schrezenmeier, H., Wagner, F.F. Transfusion (2006) [Pubmed]
  5. Human dishevelled genes constitute a DHR-containing multigene family. Semënov, M.V., Snyder, M. Genomics (1997) [Pubmed]
  6. Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Klingensmith, J., Yang, Y., Axelrod, J.D., Beier, D.R., Perrimon, N., Sussman, D.J. Mech. Dev. (1996) [Pubmed]
  7. Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia. Beasley, C., Cotter, D., Khan, N., Pollard, C., Sheppard, P., Varndell, I., Lovestone, S., Anderton, B., Everall, I. Neurosci. Lett. (2001) [Pubmed]
  8. Secondary structure, 1H, 13C and 15N resonance assignments and molecular interactions of the dishevelled DIX domain. Capelluto, D.G., Overduin, M. J. Biochem. Mol. Biol. (2005) [Pubmed]
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