Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GEM - GTP binding protein overexpressed in...

Homo sapiens

Synonyms: GTP-binding mitogen-induced T-cell protein, GTP-binding protein GEM, KIR, RAS-like protein KIR

Zamai, L. et al., Kapetanopoulos, A. et al.

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High impact information on GEM

Since efficacy of NK cell-based immunotherapy has been proven in KIR-mismatch regimens or in TRAIL-dependent apoptosis, the ability to manipulate the balance of activating and inhibitory receptors on NK cells and of their cognate ligands, as well as the sensitivity of tumor cells to apoptosis, opens new perspectives for NK cell-based immunotherapy [1].
Localization of the human mitogen-induced GTP-binding protein gem to chromosome 8q22.3 [2].

References

NK cells and cancer. Zamai, L., Ponti, C., Mirandola, P., Gobbi, G., Papa, S., Galeotti, L., Cocco, L., Vitale, M. J. Immunol. (2007) [Pubmed]
Localization of the human mitogen-induced GTP-binding protein gem to chromosome 8q22.3. Kapetanopoulos, A., Vanhove, B., Bach, F.H., de Martin, R. Genomics (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

GEM	Bos taurus
GEM	Canis lupus familiaris
gem	Danio rerio
GEM	Gallus gallus
GEM	Macaca mulatta
Gem	Mus musculus
GEM	Pan troglodytes
Gem	Rattus norvegicus
gem	Xenopus (Silurana) tropicalis

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