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Gene Review:

RNU4-5P - RNA, U4 small nuclear 5, pseudogene

Homo sapiens

Synonyms: RNU4P5, U4, U4/6

Mattaj, I.W. et al., Bae, E. et al., Jacob, M. et al., Kiss, T. et al.

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High impact information on RNU4P5

Five of these snRNAs (U1, U2, U4-6) participate in the removal of intervening sequences while the sixth (U7) plays an essential role in the 3' processing of a subset of mRNA precursors, the histone pre-mRNAs [1].
A model is proposed for the base pairing interaction of broad bean U4 RNA with broad bean U6 RNA [2].
The essential Saccharomyces cerevisiae pre-messenger RNA splicing protein 24 (Prp24) has four RNA recognition motifs (RRMs) and facilitates U6 RNA base-pairing with U4 RNA during spliceosome assembly [3].
U1, U2, U4 and U5 RNAs are capped (with trimethylguanosine) and the consensus sequence for their 6 first nucleotides is A-(Py)5p [4].

References

Small nuclear RNAs in messenger RNA and ribosomal RNA processing. Mattaj, I.W., Tollervey, D., Séraphin, B. FASEB J. (1993) [Pubmed]
Plant small nuclear RNAs. V. U4 RNA is present in broad bean plants in the form of sequence variants and is base-paired with U6 RNA. Kiss, T., Jakab, G., Antal, M., Pálfi, Z., Hegyi, H., Kis, M., Solymosy, F. Nucleic Acids Res. (1988) [Pubmed]
Structure and interactions of the first three RNA recognition motifs of splicing factor prp24. Bae, E., Reiter, N.J., Bingman, C.A., Kwan, S.S., Lee, D., Phillips, G.N., Butcher, S.E., Brow, D.A. J. Mol. Biol. (2007) [Pubmed]
A family of small nucleoplasmic RNAs with common structural features. Jacob, M., Lazar, E., Haendler, B., Gallinaro, H., Krol, A., Branlant, C. Biol. Cell (1984) [Pubmed]

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