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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pemK  -  hypothetical protein

Escherichia coli

 
 
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Disease relevance of pemK

  • It is flanked upstream by four ORFs of which one shows similarity to the dpj gene of Escherichia coli, and downstream by two ORFs of which the last shows similarity to the E. coli pemK gene [1].
 

High impact information on pemK

  • This supports our previous assumption that the PemK protein inhibits cell division, leading to cell death, whereas the PemI protein suppresses the function of the PemK protein [2].
  • The pem locus, which is responsible for the stable maintenance of the low copy number plasmid R100, contains the pemK gene, whose product has been shown to be a growth inhibitor [3].
 

Biological context of pemK

  • We cloned the pem segment of plasmid R100 containing the two genes pemI and pemK, which are responsible for stable maintenance of R100 in dividing cells, into pHS1, a temperature-sensitive replication mutant of plasmid pSC101 [4].

References

  1. Sequence of the putative alanine racemase operon in Staphylococcus aureus: insertional interruption of this operon reduces D-alanine substitution of lipoteichoic acid and autolysis. Kullik, I., Jenni, R., Berger-Bächi, B. Gene (1998) [Pubmed]
  2. The stable maintenance system pem of plasmid R100: degradation of PemI protein may allow PemK protein to inhibit cell growth. Tsuchimoto, S., Nishimura, Y., Ohtsubo, E. J. Bacteriol. (1992) [Pubmed]
  3. Isolation of temperature-sensitive aminoacyl-tRNA synthetase mutants from an Escherichia coli strain harboring the pemK plasmid. Masuda, Y., Tsuchimoto, S., Nishimura, A., Ohtsubo, E. Mol. Gen. Genet. (1993) [Pubmed]
  4. Effect of the pem system on stable maintenance of plasmid R100 in various Escherichia coli hosts. Tsuchimoto, S., Ohtsubo, E. Mol. Gen. Genet. (1989) [Pubmed]
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