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Gene Review

pecM  -  PecM

Escherichia coli

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Disease relevance of pecM

  • The pecS gene encodes a 166 amino acid polypeptide that shows similarity to the MprA regulatory protein of Escherichia coli whereas the pecM gene encodes a 297 amino acid polypeptide that was shown to be an integral membrane protein [1].
  • The PecM protein is necessary for the DNA-binding capacity of the PecS repressor, one of the regulators of virulence-factor synthesis in Erwinia chrysanthemi [2].

High impact information on pecM

  • The nucleotide sequences of pecS and pecM were determined [1].
  • Measurement of the extrusion of the blue pigment indigoidine by the E. chrysanthemi derivative isogenic mutants pecS, pecM and pecS-pecM revealed that PecM is required for complete efflux of the pigment [3].
  • We analyzed the membrane topology of PecM using the beta-lactamase gene fusion system and obtained the following unique characteristics [3].
  • Computer-aided hydropathy analysis of PecM predicted the presence of between 8 to 10 potential transmembrane segments [3].

Chemical compound and disease context of pecM

  • The PecM protein of the phytopathogenic bacterium Erwinia chrysanthemi, membrane topology and possible involvement in the efflux of the blue pigment indigoidine [3].


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