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Gene Review: 

coi  -  C one inactivation

Enterobacteria phage P1

 
 
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Disease relevance of coi

  • Maintenance of the prophage state requires the continuous expression of two repressors: (i) C1 is a protein which negatively regulates the expression of lytic genes including the C1 inactivator gene coi, and (ii) C4 is an antisense RNA which specifically inhibits the synthesis of an anti-repressor Ant [1].
  • The temperate phage P1 encodes two genes whose products antagonize the action of the phage's C1 repressor of lytic functions, namely a distantly linked antirepressor gene, ant, and a closely linked c1 inactivator gene, coi [2].
 

High impact information on coi

  • A c1 inactivator gene, coi, was defined by mutations in immC that suppress the virulence of the P1virC mutation [3].
 

Associations of coi with chemical compounds

  • When the C1 source also included a 0.7-kilobase region upstream from C1 which encodes the coi gene, repression of both c1::lacZ and ref::lacZ by C1 alone or by C1 plus Bof was much less effective, as if Coi interfered with C1 repressor function [4].

References

  1. The tripartite immunity system of phages P1 and P7. Heinrich, J., Velleman, M., Schuster, H. FEMS Microbiol. Rev. (1995) [Pubmed]
  2. C1 repressor of phage P1 is inactivated by noncovalent binding of P1 Coi protein. Heinzel, T., Velleman, M., Schuster, H. J. Biol. Chem. (1992) [Pubmed]
  3. The c1 repressor inactivator protein coi of bacteriophage P1. Cloning and expression of coi and its interference with c1 repressor function. Heinzel, T., Velleman, M., Schuster, H. J. Biol. Chem. (1990) [Pubmed]
  4. The bof gene of bacteriophage P1: DNA sequence and evidence for roles in regulation of phage c1 and ref genes. Schaefer, T.S., Hays, J.B. J. Bacteriol. (1990) [Pubmed]
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