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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AMY1C  -  amylase, alpha 1C (salivary)

Homo sapiens

 
 
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Disease relevance of AMY1C

  • The data demonstrate that the functional tissue-specific promoter of human AMY1C is derived from inserted sequences and that parotid expression can be conferred by sequences derived solely from the retrovirus [1].
 

High impact information on AMY1C

  • A 1-kb fragment of AMY1C (-1003 to +2) was found to be sufficient for parotid-specific expression of a human growth hormone reporter gene [1].
  • This study demonstrates that adenoviral vectors containing the relatively cell/tissue-specific AMY1C or KLK1 promoters may be useful for targeting therapeutic gene expression in salivary glands [2].
  • The short haplotype contains two pancreatic genes (AMY2A and AMY2B) and one salivary amylase gene (AMY1C), arranged in the order 2B-2A-1C, encompassing a total length of approximately 100 kb [3].

References

  1. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Ting, C.N., Rosenberg, M.P., Snow, C.M., Samuelson, L.C., Meisler, M.H. Genes Dev. (1992) [Pubmed]
  2. Evaluation of salivary gland acinar and ductal cell-specific promoters in vivo with recombinant adenoviral vectors. Zheng, C., Hoque, A.T., Braddon, V.R., Baum, B.J., O'Connell, B.C. Hum. Gene Ther. (2001) [Pubmed]
  3. The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes. Groot, P.C., Bleeker, M.J., Pronk, J.C., Arwert, F., Mager, W.H., Planta, R.J., Eriksson, A.W., Frants, R.R. Genomics (1989) [Pubmed]
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