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Gene Review:

D11Nds1 - DNA segment, Chr 11, Nuffield Department...

Mus musculus

Grattan, M. et al., Blackburn, C.C. et al.

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High impact information on D11Nds1

This B6-derived region expressed in NOD.B6Idd4A mice maps between the D11Nds1 (43.8 cM) and D11Mit38/D11Mit325 (49.0 cM) markers and dramatically reduces the development of both insulitis and type 1 diabetes [1].
NOD.B6Idd4B and NOD.B6Idd4C mice, which carry a smaller B6-derived segment of chromosome 11 that spans <5.2 cM distal to D11Nds1, exhibit protection against type 1 diabetes with the restoration of T-cell proliferation [1].
Thus, nude lies 1.4 cM distal to D11Nds1 and is 0.5 cM proximal to D11Mit8 [2].
D11Nds1 and Evi-2/D11Mit34 thus define the new proximal and distal boundaries, respectively, for the nu interval [2].

Biological context of D11Nds1

In this study, exclusion mapping of a panel of congenic nude strains was used to place the nude locus between the microsatellite loci D11Nds1 and D11Mit8 [2].

References

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Grattan, M., Mi, Q.S., Meagher, C., Delovitch, T.L. Diabetes (2002) [Pubmed]
A high-resolution map of the chromosomal region surrounding the nude gene. Blackburn, C.C., Griffith, J., Morahan, G. Genomics (1995) [Pubmed]

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