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Gene Review:

IGHA - immunoglobulin heavy constant alpha

Bos taurus

Francus, T. et al., Zhou, H. et al., Zhou, H. et al., Rabbani, H. et al.

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High impact information on IGHA

In this study, the IGHA gene was investigated in goats using PCR-single-strand conformational polymorphism (SSCP) analysis and DNA sequencing [1].
Identification of allelic polymorphism in the caprine IGHA gene [1].
Three novel amino acid sequences of ovine IGHA were also predicted, and variation in these sequences might not only affect antigen recognition but also susceptibility to cleavage by bacterial or parasitic proteases [2].
Our data also indicate that the cattle heavy chain locus spans approximately 400 kilobases from IGHM to IGHA and encodes only three IgG subclasses, all of which are transcriptionally active [3].
In a cell transfer system, using the allotype congenic pair C57BL/6 (Ihgb) and B.C-9 (Igha), we established that the antibody response to dinitrophenylated bovine gamma globulin measured by solid state radioimmunoassay was only of donor allotype, both in the primary and in the secondary responses and regardless of the age of the cell donor [4].

References

Identification of allelic polymorphism in the caprine IGHA gene. Zhou, H., Hickford, J.G., Fang, Q. Dev. Comp. Immunol. (2006) [Pubmed]
Polymorphism of the IGHA gene in sheep. Zhou, H., Hickford, J.G., Fang, Q. Immunogenetics (2005) [Pubmed]
Polymorphism of the IGHG3 gene in cattle. Rabbani, H., Brown, W.R., Butler, J.E., Hammarström, L. Immunogenetics (1997) [Pubmed]
Evidence that only donor cells produce antibody in a lethally irradiated cell transfer recipient. Francus, T., Siskind, G.W. J. Immunol. Methods (1982) [Pubmed]

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