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MAPT  -  microtubule-associated protein tau

Bos taurus

 
 
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Psychiatry related information on MAPT

 

High impact information on MAPT

 

Chemical compound and disease context of MAPT

  • The results provide initial evidence that TPKI/GSK-3 beta/FA after heparin potentiation may represent one of the most potent systems possibly involved in the abnormal phosphorylation of PHF-tau and neuronal degeneration in Alzheimer disease brains [7].
 

Analytical, diagnostic and therapeutic context of MAPT

References

  1. Transglutaminase catalyzes the formation of sodium dodecyl sulfate-insoluble, Alz-50-reactive polymers of tau. Dudek, S.M., Johnson, G.V. J. Neurochem. (1993) [Pubmed]
  2. Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau. Liao, H., Li, Y., Brautigan, D.L., Gundersen, G.G. J. Biol. Chem. (1998) [Pubmed]
  3. In vitro polymerization of embryonic MAP-2c and fragments of the MAP-2 microtubule binding region into structures resembling paired helical filaments. DeTure, M.A., Zhang, E.Y., Bubb, M.R., Purich, D.L. J. Biol. Chem. (1996) [Pubmed]
  4. Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain. Litersky, J.M., Johnson, G.V. J. Biol. Chem. (1992) [Pubmed]
  5. Mobilization of intrasporozoite Ca2+ is essential for Theileria parva sporozoite invasion of bovine lymphocytes. Shaw, M.K. Eur. J. Cell Biol. (1995) [Pubmed]
  6. Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells. Saragoni, L., Hernández, P., Maccioni, R.B. Neurochem. Res. (2000) [Pubmed]
  7. Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain. Song, J.S., Yang, S.D. J. Protein Chem. (1995) [Pubmed]
  8. The organization of the microtubule associated protein tau in Alzheimer paired helical filaments. Ruben, G.C., Iqbal, K., Grundke-Iqbal, I., Johnson, J.E. Brain Res. (1993) [Pubmed]
 
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