The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neurites


Psychiatry related information on Neurites


High impact information on Neurites

  • After dissociation from PARP-1, KIF4 enters into the cytoplasm from the nucleus and moves to the distal part of neurites in a microtubule-dependent manner [11].
  • The expression of the nonphosphorylated form of CRMP-2 or inhibition of GSK-3beta induced the formation of multiple axon-like neurites in hippocampal neurons [12].
  • Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth [13].
  • Here, we report that selection of the future axon among neurites of a cultured hippocampal neuron requires the activity of growth factor receptor tyrosine kinase, phosphatidylinositol 3-kinase (PI 3-kinase), as well as atypical protein kinase C (aPKC) [14].
  • We speculate that through this interaction, TM4SF2 might have a role in the control of neurite outgrowth [15].

Chemical compound and disease context of Neurites


Biological context of Neurites

  • F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension [21].
  • Indeed, the co-localization of RAGE and amphoterin at the leading edge of advancing neurites indicated their potential contribution to cellular migration, and in pathologies such as tumour invasion [22].
  • Up-regulation of Notch activity was concomitant with an increase in the number of interneuronal contacts and cessation of neurite growth [23].
  • None of five other proteases were inhibited, and the ability of lactacystin analogs to inhibit cell cycle progression and induce neurite outgrowth correlated with their ability to inhibit the proteasome [24].
  • Additional studies have identified a potential coreceptor for NgR as p75(NTR), and a second-messenger pathway involving RhoA that inhibits neurite elongation [25].

Anatomical context of Neurites


Associations of Neurites with chemical compounds

  • Cells with neurites are incubated with the microtubule-depolymerizing drug Nocodazole [30].
  • Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth [31].
  • We have previously shown that striatal target neurones influence the biochemical maturation of ascending mesencephalic dopamine (DA) cells in culture, as well as the elongation rate of DA neurites [32].
  • Neurite formation induced by cyclic AMP was unaffected by injection of anti-p21 antibody [33].
  • One candidate molecule is laminin, a major glycoprotein of basal laminae which has been shown to induce a wide variety of embryonic neurones to extend neurites in culture [34].

Gene context of Neurites


Analytical, diagnostic and therapeutic context of Neurites


  1. A threshold effect of the major isoforms of NCAM on neurite outgrowth. Doherty, P., Fruns, M., Seaton, P., Dickson, G., Barton, C.H., Sears, T.A., Walsh, F.S. Nature (1990) [Pubmed]
  2. A Drosophila model of Parkinson's disease. Feany, M.B., Bender, W.W. Nature (2000) [Pubmed]
  3. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., Narumiya, S. Science (1999) [Pubmed]
  4. Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. Ferreira, A., Kosik, K.S., Greengard, P., Han, H.Q. Science (1994) [Pubmed]
  5. ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. Antic, D., Lu, N., Keene, J.D. Genes Dev. (1999) [Pubmed]
  6. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. Small, D.H., Nurcombe, V., Reed, G., Clarris, H., Moir, R., Beyreuther, K., Masters, C.L. J. Neurosci. (1994) [Pubmed]
  7. Immunohistochemical verification of senile and kuru plaques in Creutzfeldt-Jakob disease and the allied disease. Kitamoto, T., Tateishi, J., Sato, Y. Ann. Neurol. (1988) [Pubmed]
  8. Neuritogenesis induced by thyroid hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase-phosphatidylinositol 3-kinase pathways and involves modulation of extracellular matrix proteins. Martinez, R., Gomes, F.C. J. Biol. Chem. (2002) [Pubmed]
  9. Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Hurtig, H.I., Trojanowski, J.Q., Galvin, J., Ewbank, D., Schmidt, M.L., Lee, V.M., Clark, C.M., Glosser, G., Stern, M.B., Gollomp, S.M., Arnold, S.E. Neurology (2000) [Pubmed]
  10. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. Laeng, P., Pitts, R.L., Lemire, A.L., Drabik, C.E., Weiner, A., Tang, H., Thyagarajan, R., Mallon, B.S., Altar, C.A. J. Neurochem. (2004) [Pubmed]
  11. KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. Midorikawa, R., Takei, Y., Hirokawa, N. Cell (2006) [Pubmed]
  12. GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Yoshimura, T., Kawano, Y., Arimura, N., Kawabata, S., Kikuchi, A., Kaibuchi, K. Cell (2005) [Pubmed]
  13. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Lu, W., Yamamoto, V., Ortega, B., Baltimore, D. Cell (2004) [Pubmed]
  14. Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Shi, S.H., Jan, L.Y., Jan, Y.N. Cell (2003) [Pubmed]
  15. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Zemni, R., Bienvenu, T., Vinet, M.C., Sefiani, A., Carrié, A., Billuart, P., McDonell, N., Couvert, P., Francis, F., Chafey, P., Fauchereau, F., Friocourt, G., des Portes, V., Cardona, A., Frints, S., Meindl, A., Brandau, O., Ronce, N., Moraine, C., van Bokhoven, H., Ropers, H.H., Sudbrak, R., Kahn, A., Fryns, J.P., Beldjord, C., Chelly, J. Nat. Genet. (2000) [Pubmed]
  16. Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels. Arcangeli, A., Becchetti, A., Mannini, A., Mugnai, G., De Filippi, P., Tarone, G., Del Bene, M.R., Barletta, E., Wanke, E., Olivotto, M. J. Cell Biol. (1993) [Pubmed]
  17. Laminin promotes neuritic regeneration from cultured peripheral and central neurons. Manthorpe, M., Engvall, E., Ruoslahti, E., Longo, F.M., Davis, G.E., Varon, S. J. Cell Biol. (1983) [Pubmed]
  18. Cytochalasin separates microtubule disassembly from loss of asymmetric morphology. Solomon, F., Magendantz, M. J. Cell Biol. (1981) [Pubmed]
  19. Specific high-affinity binding and biologic action of retinoic acid in human neuroblastoma cell lines. Haussler, M., Sidell, N., Kelly, M., Donaldson, C., Altman, A., Mangelsdorf, D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  20. Binding properties of a cell adhesion molecule from neural tissue. Rutishauser, U., Hoffman, S., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  21. F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension. Klar, A., Baldassare, M., Jessell, T.M. Cell (1992) [Pubmed]
  22. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Taguchi, A., Blood, D.C., del Toro, G., Canet, A., Lee, D.C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., Hofmann, M.A., Kislinger, T., Ingram, M., Lu, A., Tanaka, H., Hori, O., Ogawa, S., Stern, D.M., Schmidt, A.M. Nature (2000) [Pubmed]
  23. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Sestan, N., Artavanis-Tsakonas, S., Rakic, P. Science (1999) [Pubmed]
  24. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J., Schreiber, S.L. Science (1995) [Pubmed]
  25. The Nogo-66 receptor: focusing myelin inhibition of axon regeneration. McGee, A.W., Strittmatter, S.M. Trends Neurosci. (2003) [Pubmed]
  26. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Steiner, J.P., Connolly, M.A., Valentine, H.L., Hamilton, G.S., Dawson, T.M., Hester, L., Snyder, S.H. Nat. Med. (1997) [Pubmed]
  27. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nikolic, M., Chou, M.M., Lu, W., Mayer, B.J., Tsai, L.H. Nature (1998) [Pubmed]
  28. Basal lamina glycoproteins are produced by neuroblastoma cells. Alitalo, K., Kurkinen, M., Vaheri, A., Virtanen, I., Rohde, H., Timpl, R. Nature (1980) [Pubmed]
  29. Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein. Tiveron, M.C., Barboni, E., Pliego Rivero, F.B., Gormley, A.M., Seeley, P.J., Grosveld, F., Morris, R. Nature (1992) [Pubmed]
  30. Neuroblastoma cells recapitulate their detailed neurite morphologies after reversible microtubule disassembly. Solomon, F. Cell (1980) [Pubmed]
  31. Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth. Condic, M.L., Letourneau, P.C. Nature (1997) [Pubmed]
  32. Glial heterogeneity may define the three-dimensional shape of mouse mesencephalic dopaminergic neurones. Denis-Donini, S., Glowinski, J., Prochiantz, A. Nature (1984) [Pubmed]
  33. Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21. Hagag, N., Halegoua, S., Viola, M. Nature (1986) [Pubmed]
  34. Retinal ganglion cells lose response to laminin with maturation. Cohen, J., Burne, J.F., Winter, J., Bartlett, P. Nature (1986) [Pubmed]
  35. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Wang, K.C., Koprivica, V., Kim, J.A., Sivasankaran, R., Guo, Y., Neve, R.L., He, Z. Nature (2002) [Pubmed]
  36. Neurotoxicity induces cleavage of p35 to p25 by calpain. Lee, M.S., Kwon, Y.T., Li, M., Peng, J., Friedlander, R.M., Tsai, L.H. Nature (2000) [Pubmed]
  37. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Whitmarsh, A.J., Kuan, C.Y., Kennedy, N.J., Kelkar, N., Haydar, T.F., Mordes, J.P., Appel, M., Rossini, A.A., Jones, S.N., Flavell, R.A., Rakic, P., Davis, R.J. Genes Dev. (2001) [Pubmed]
  38. Focal adhesion kinase in netrin-1 signaling. Ren, X.R., Ming, G.L., Xie, Y., Hong, Y., Sun, D.M., Zhao, Z.Q., Feng, Z., Wang, Q., Shim, S., Chen, Z.F., Song, H.J., Mei, L., Xiong, W.C. Nat. Neurosci. (2004) [Pubmed]
  39. Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Takei, K., Shin, R.M., Inoue, T., Kato, K., Mikoshiba, K. Science (1998) [Pubmed]
  40. Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Minichiello, L., Casagranda, F., Tatche, R.S., Stucky, C.L., Postigo, A., Lewin, G.R., Davies, A.M., Klein, R. Neuron (1998) [Pubmed]
  41. The polymeric immunoglobulin receptor accumulates in specialized endosomes but not synaptic vesicles within the neurites of transfected neuroendocrine PC12 cells. Bonzelius, F., Herman, G.A., Cardone, M.H., Mostov, K.E., Kelly, R.B. J. Cell Biol. (1994) [Pubmed]
  42. Neuronal regulation of astroglial morphology and proliferation in vitro. Hatten, M.E. J. Cell Biol. (1985) [Pubmed]
  43. The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis. Borner, C., Martinou, I., Mattmann, C., Irmler, M., Schaerer, E., Martinou, J.C., Tschopp, J. J. Cell Biol. (1994) [Pubmed]
WikiGenes - Universities