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Gene Review

CABP4  -  calcium binding protein 4

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Disease relevance of CABP4

  • The phenotype of Cabp4(-/-) mice shares similarities with that of incomplete congenital stationary night blindness (CSNB2) patients [1].

High impact information on CABP4

  • The outer plexiform layer, which contains the photoreceptor synapses with secondary neurons, was thinner in the Cabp4(-/-) mice than in control mice [1].
  • Here we show that CaBP4 is specifically expressed in photoreceptors, where it is localized to synaptic terminals [1].
  • Cabp4(-/-) retinas also had ectopic synapses originating from rod bipolar and horizontal cells tha HJt extended into the outer nuclear layer [1].

Associations of CABP4 with chemical compounds

  • These observations indicate that CaBP4 is important for normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals [1].


  1. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Haeseleer, F., Imanishi, Y., Maeda, T., Possin, D.E., Maeda, A., Lee, A., Rieke, F., Palczewski, K. Nat. Neurosci. (2004) [Pubmed]
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