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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ASB15  -  ankyrin repeat and SOCS box containing 15

Bos taurus

 
 
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Disease relevance of ASB15

  • Because beta-adrenergic receptor agonists are known to stimulate muscle hypertrophy, the objective of this study was to determine whether ASB15 regulates cellular processes that contribute to muscle growth [1].
 

High impact information on ASB15

  • A consistent effect of ASB15 overexpression was observed in vivo, where ectopic expression of ASB15 increased skeletal muscle fiber area (P<0.0001) after 9 days [1].
  • Expression of ASB15-SOCS altered differentiation of myoblasts, resulting in detachment of cells from culture plates [1].
  • Together, these results suggest ASB15 participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells [1].
  • Characterization of a bovine gene encoding an ankyrin repeat and SOCS box protein (ASB15) [2].
 

Anatomical context of ASB15

References

  1. Ankyrin repeat and SOCS box protein 15 regulates protein synthesis in skeletal muscle. McDaneld, T.G., Hannon, K., Moody, D.E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  2. Characterization of a bovine gene encoding an ankyrin repeat and SOCS box protein (ASB15). McDaneld, T.G., Moody, D.E. Anim. Genet. (2003) [Pubmed]
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