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Gene Review: 

UPK3A  -  uroplakin 3A

Bos taurus

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Disease relevance of UPK3A

  • The putative role of UPIII sialylated glycans in enhancing the uropathogenicity of E. coli expressing type S adhesins is discussed [1].
 

High impact information on UPK3A

  • Previous studies indicate that the outer leaflet of AUM is composed of crystalline patches of 12-nm protein particles, and that bovine AUMs contain three major proteins: the 27- to 28-kD uroplakin I, the 15-kD uroplakin II and the 47-kD uroplakin III [2].
  • TaqI and BglII RFLPs for the bovine uroplakin III loci UPK3A and UPK3B [3].
  • Terminal glycosylation of bovine uroplakin III, one of the major integral-membrane glycoproteins of mammalian bladder [1].
  • Consistently, alpha 2,3- and alpha 2, 6-sialyltransferase, as well as alpha 1,3-galactosyltransferase were found to be present in the cells detached from the luminal side of bovine bladder, which are responsible for the UPIII biosynthesis [1].
 

Analytical, diagnostic and therapeutic context of UPK3A

  • Immunoblotting showed that AU1, AU2 and AU3 antibodies all recognized the N-terminal extracellular domain of bovine UPIII [4].

References

  1. Terminal glycosylation of bovine uroplakin III, one of the major integral-membrane glycoproteins of mammalian bladder. Malagolini, N., Cavallone, D., Wu, X.R., Serafini-Cessi, F. Biochim. Biophys. Acta (2000) [Pubmed]
  2. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. Yu, J., Lin, J.H., Wu, X.R., Sun, T.T. J. Cell Biol. (1994) [Pubmed]
  3. TaqI and BglII RFLPs for the bovine uroplakin III loci UPK3A and UPK3B. Ryan, A.M., Womack, J.E., Wu, X.R., Sun, T.T. Anim. Genet. (1994) [Pubmed]
  4. Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder? Riedel, I., Liang, F.X., Deng, F.M., Tu, L., Kreibich, G., Wu, X.R., Sun, T.T., Hergt, M., Moll, R. Eur. J. Cell Biol. (2005) [Pubmed]
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