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MeSH Review


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Disease relevance of Glycosylation


Psychiatry related information on Glycosylation


High impact information on Glycosylation

  • Indeed, chemically, prolactin appears in a multiplicity of posttranslational forms ranging from size variants to chemical modifications such as phosphorylation or glycosylation [11].
  • We infer that beta cell glucose-transporter glycosylation mediates a link between diet and insulin production that typically suppresses the pathogenesis of type 2 diabetes [12].
  • Remarkably, the induction of diabetes by chronic ingestion of a high-fat diet is associated with reduced GlcNAcT-IV expression and attenuated Glut-2 glycosylation coincident with Glut-2 endocytosis [12].
  • Gene replacement in dystroglycan-deficient muscle demonstrates that the dystroglycan C-terminal domain is sufficient only for dystrophin-glycoprotein complex assembly, but to prevent muscle degeneration the expression of a functional dystroglycan through LARGE recognition and glycosylation is required [13].
  • Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency [14].

Chemical compound and disease context of Glycosylation


Biological context of Glycosylation


Anatomical context of Glycosylation


Associations of Glycosylation with chemical compounds

  • Tunicamycin specifically inhibits glycosylation of asparaginyl residues of glycoproteins [27].
  • Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation [29].
  • The sequence predicts a cytoplasmic domain of 50 amino acids at the COOH terminus, followed in order by a membrane-spanning region of 27 hydrophobic amino acids and an externally disposed stretch of 42 amino acids, that is rich in serine and threonine residues and appears to be the site of O-linked glycosylation [30].
  • Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin [31].
  • Treatment with monensin caused accumulation in the cell of a form of G1 with partial sensitivity toward endo H, suggesting that monensin may act to inhibit the glycosylation process directly [32].

Gene context of Glycosylation


Analytical, diagnostic and therapeutic context of Glycosylation


  1. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Farzan, M., Mirzabekov, T., Kolchinsky, P., Wyatt, R., Cayabyab, M., Gerard, N.P., Gerard, C., Sodroski, J., Choe, H. Cell (1999) [Pubmed]
  2. Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Matthijs, G., Schollen, E., Pardon, E., Veiga-Da-Cunha, M., Jaeken, J., Cassiman, J.J., Van Schaftingen, E. Nat. Genet. (1997) [Pubmed]
  3. Expression of the HTLV-III envelope gene by a recombinant vaccinia virus. Chakrabarti, S., Robert-Guroff, M., Wong-Staal, F., Gallo, R.C., Moss, B. Nature (1986) [Pubmed]
  4. A role for carbohydrates in immune evasion in AIDS. Reitter, J.N., Means, R.E., Desrosiers, R.C. Nat. Med. (1998) [Pubmed]
  5. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Parekh, R.B., Dwek, R.A., Sutton, B.J., Fernandes, D.L., Leung, A., Stanworth, D., Rademacher, T.W., Mizuochi, T., Taniguchi, T., Matsuta, K. Nature (1985) [Pubmed]
  6. Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition. Fodero, L.R., Sáez-Valero, J., McLean, C.A., Martins, R.N., Beyreuther, K., Masters, C.L., Robertson, T.A., Small, D.H. J. Neurochem. (2002) [Pubmed]
  7. Altered glycosylation of acetylcholinesterase in Creutzfeldt-Jakob disease. Silveyra, M.X., Cuadrado-Corrales, N., Marcos, A., Barquero, M.S., Rábano, A., Calero, M., Sáez-Valero, J. J. Neurochem. (2006) [Pubmed]
  8. Differential susceptibility of transferrin glycoforms to chymotrypsin: a proteomics approach to the detection of carbohydrate-deficient transferrin. Valmu, L., Kalkkinen, N., Husa, A., Rye, P.D. Biochemistry (2005) [Pubmed]
  9. Changes in the glycosylation pattern of circulating gonadotropins after acute administration of gonadotropin-releasing hormone in patients with anorexia nervosa. Savastano, S., Tommaselli, A.P., Valentino, R., Luciano, A., Gigante, M., Randazzo, G., Contaldo, F., Scalfi, L., Lombardi, G. Eur. J. Endocrinol. (1998) [Pubmed]
  10. Transformation-sensitive cell surface protein: isolation, characterization, and role in cellular morphology and adhesion. Yamada, K.M., Olden, K., Pastan, I. Ann. N. Y. Acad. Sci. (1978) [Pubmed]
  11. Prolactin: structure, function, and regulation of secretion. Freeman, M.E., Kanyicska, B., Lerant, A., Nagy, G. Physiol. Rev. (2000) [Pubmed]
  12. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., Marth, J.D. Cell (2005) [Pubmed]
  13. Molecular recognition by LARGE is essential for expression of functional dystroglycan. Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y.M., Muschler, J., Dumanski, J.P., Michele, D.E., Oldstone, M.B., Campbell, K.P. Cell (2004) [Pubmed]
  14. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Lübke, T., Marquardt, T., Etzioni, A., Hartmann, E., von Figura, K., Körner, C. Nat. Genet. (2001) [Pubmed]
  15. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Brownlee, M., Vlassara, H., Kooney, A., Ulrich, P., Cerami, A. Science (1986) [Pubmed]
  16. Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. Rogerson, S.J., Chaiyaroj, S.C., Ng, K., Reeder, J.C., Brown, G.V. J. Exp. Med. (1995) [Pubmed]
  17. Nonenzymatic glycosylation of erythrocyte membrane proteins. Relevance to diabetes. Miller, J.A., Gravallese, E., Bunn, H.F. J. Clin. Invest. (1980) [Pubmed]
  18. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Reimertz, C., Kögel, D., Rami, A., Chittenden, T., Prehn, J.H. J. Cell Biol. (2003) [Pubmed]
  19. Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. Bartolazzi, A., Nocks, A., Aruffo, A., Spring, F., Stamenkovic, I. J. Cell Biol. (1996) [Pubmed]
  20. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Gros, P., Croop, J., Housman, D. Cell (1986) [Pubmed]
  21. Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Kaptein, E.M. Endocr. Rev. (1996) [Pubmed]
  22. Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein. Boackle, S.A., Holers, V.M., Chen, X., Szakonyi, G., Karp, D.R., Wakeland, E.K., Morel, L. Immunity (2001) [Pubmed]
  23. Retrograde transport on the COG railway. Ungar, D., Oka, T., Krieger, M., Hughson, F.M. Trends Cell Biol. (2006) [Pubmed]
  24. The synthesis and properties of T25 blycoprotein in Thy-1-negative mutant lymphoma cells. Trowbridge, I.S., Hyman, R., Mazauskas, C. Cell (1978) [Pubmed]
  25. Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and beta 2-microglobulin. Dobberstein, B., Garoff, H., Warren, G., Robinson, P.J. Cell (1979) [Pubmed]
  26. The erythrocyte anion transport protein is contranslationally inserted into microsomes. Braell, W.A., Lodish, H.F. Cell (1982) [Pubmed]
  27. Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: compaction and trophoblast adhesion. Surani, M.A. Cell (1979) [Pubmed]
  28. Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion. Thorens, B., Vassalli, P. Nature (1986) [Pubmed]
  29. Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation. Matlin, K.S., Simons, K. Cell (1983) [Pubmed]
  30. Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Russell, D.W., Schneider, W.J., Yamamoto, T., Luskey, K.L., Brown, M.S., Goldstein, J.L. Cell (1984) [Pubmed]
  31. Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin. Kelly, W.G., Hart, G.W. Cell (1989) [Pubmed]
  32. A membrane glycoprotein that accumulates intracellularly: cellular processing of the large glycoprotein of LaCrosse virus. Madoff, D.H., Lenard, J. Cell (1982) [Pubmed]
  33. Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59. Bodian, D.L., Davis, S.J., Morgan, B.P., Rushmere, N.K. J. Exp. Med. (1997) [Pubmed]
  34. N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6. Dela Cruz, C.S., Lee, Y., Viswanathan, S.R., El-Guindy, A.S., Gerlach, J., Nikiforow, S., Shedd, D., Gradoville, L., Miller, G. J. Exp. Med. (2004) [Pubmed]
  35. Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie). Kim, S., Westphal, V., Srikrishna, G., Mehta, D.P., Peterson, S., Filiano, J., Karnes, P.S., Patterson, M.C., Freeze, H.H. J. Clin. Invest. (2000) [Pubmed]
  36. A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If). Kranz, C., Denecke, J., Lehrman, M.A., Ray, S., Kienz, P., Kreissel, G., Sagi, D., Peter-Katalinic, J., Freeze, H.H., Schmid, T., Jackowski-Dohrmann, S., Harms, E., Marquardt, T. J. Clin. Invest. (2001) [Pubmed]
  37. Abnormalities in the glycosylation of immunoglobulin heavy chain and an h-2 transplantation antigen in a mouse myeloma mutant. Weitzman, S., Nathenson, S.G., Scharff, M.D. Cell (1977) [Pubmed]
  38. Compound missense mutations in the sodium/D-glucose cotransporter result in trafficking defects. Martín, M.G., Lostao, M.P., Turk, E., Lam, J., Kreman, M., Wright, E.M. Gastroenterology (1997) [Pubmed]
  39. Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin. Tytgat, K.M., Büller, H.A., Opdam, F.J., Kim, Y.S., Einerhand, A.W., Dekker, J. Gastroenterology (1994) [Pubmed]
  40. The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins. Dorner, A.J., Bole, D.G., Kaufman, R.J. J. Cell Biol. (1987) [Pubmed]
  41. Isolation of a murine Ly-6 cDNA reveals a new multigene family. LeClair, K.P., Palfree, R.G., Flood, P.M., Hammerling, U., Bothwell, A. EMBO J. (1986) [Pubmed]
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