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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Glycosylation

 
 
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Disease relevance of Glycosylation

 

Psychiatry related information on Glycosylation

 

High impact information on Glycosylation

  • Indeed, chemically, prolactin appears in a multiplicity of posttranslational forms ranging from size variants to chemical modifications such as phosphorylation or glycosylation [11].
  • We infer that beta cell glucose-transporter glycosylation mediates a link between diet and insulin production that typically suppresses the pathogenesis of type 2 diabetes [12].
  • Remarkably, the induction of diabetes by chronic ingestion of a high-fat diet is associated with reduced GlcNAcT-IV expression and attenuated Glut-2 glycosylation coincident with Glut-2 endocytosis [12].
  • Gene replacement in dystroglycan-deficient muscle demonstrates that the dystroglycan C-terminal domain is sufficient only for dystrophin-glycoprotein complex assembly, but to prevent muscle degeneration the expression of a functional dystroglycan through LARGE recognition and glycosylation is required [13].
  • Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency [14].
 

Chemical compound and disease context of Glycosylation

 

Biological context of Glycosylation

 

Anatomical context of Glycosylation

 

Associations of Glycosylation with chemical compounds

  • Tunicamycin specifically inhibits glycosylation of asparaginyl residues of glycoproteins [27].
  • Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation [29].
  • The sequence predicts a cytoplasmic domain of 50 amino acids at the COOH terminus, followed in order by a membrane-spanning region of 27 hydrophobic amino acids and an externally disposed stretch of 42 amino acids, that is rich in serine and threonine residues and appears to be the site of O-linked glycosylation [30].
  • Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin [31].
  • Treatment with monensin caused accumulation in the cell of a form of G1 with partial sensitivity toward endo H, suggesting that monensin may act to inhibit the glycosylation process directly [32].
 

Gene context of Glycosylation

 

Analytical, diagnostic and therapeutic context of Glycosylation

References

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