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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

OR4N4  -  olfactory receptor, family 4, subfamily N,...

Homo sapiens

Synonyms: OR15-1, OR15-5, Olfactory receptor 4N4, Olfactory receptor OR15-1, Olfactory receptor OR15-5
 
 
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High impact information on OR4N4

  • It has been suggested that D genes with irregular recombination signal sequences (DIR) and chromosome 15 open reading frames (OR15) can replace conventional D genes, that two D genes or inverted D genes may be used and that the repertoire can be further diversified by heavy chain V gene (V(H)) replacement [1].
  • From these cell lines two types of germline IgV gene transcripts were isolated: a transcript containing the IGKV4-1 gene and a germline IGHV-1 transcript nearly identical to IGHV1/OR15-1 (HC15-1, DP-1), an orphon VH gene on chromosome 15 [2].

References

  1. No evidence for the use of DIR, D-D fusions, chromosome 15 open reading frames or Vreplacement in the peripheral repertoire was found on application of an improved algorithm, JointML, to 6329 human immunoglobulin H rearrangements. Ohm-Laursen, L., Nielsen, M., Larsen, S.R., Barington, T. Immunology (2006) [Pubmed]
  2. A pro-B-cell stage characterized by germline Ig transcription without surrogate light chain expression. Thompson, A., Brouns, G.S., Schuurman, R.K., Borst, J., Timmers, E. Immunogenetics (1998) [Pubmed]
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