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Gene Review

rprA  -  ncRNA

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1686, IS083, JWR0203, psrA5
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High impact information on rprA

  • Mutations in rprA and compensating mutations in the rpoS leader demonstrate that RprA interacts with the same region of the RpoS leader as DsrA [1].
  • The rprA gene encodes a 106 nucleotide regulatory RNA [2].
  • Furthermore, low-temperature growth or constitutive RcsC activation had only modest effects on RpoS expression, and these increases were, respectively, independent of dsrA or rprA function [3].
  • Sequencing of an rcsC allele, rcsC137, that leads to high-level constitutive expression of both cps and rprA suggests that the response regulator domain of RcsC plays a role in negatively regulating the kinase activity of RcsC [4].


  1. Regulation and mode of action of the second small RNA activator of RpoS translation, RprA. Majdalani, N., Hernandez, D., Gottesman, S. Mol. Microbiol. (2002) [Pubmed]
  2. Regulation of RpoS by a novel small RNA: the characterization of RprA. Majdalani, N., Chen, S., Murrow, J., St John, K., Gottesman, S. Mol. Microbiol. (2001) [Pubmed]
  3. Limited role for the DsrA and RprA regulatory RNAs in rpoS regulation in Salmonella enterica. Jones, A.M., Goodwill, A., Elliott, T. J. Bacteriol. (2006) [Pubmed]
  4. Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli. Majdalani, N., Heck, M., Stout, V., Gottesman, S. J. Bacteriol. (2005) [Pubmed]
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