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Gene Review

rcsC  -  hybrid sensory kinase in two-component...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2211, JW5917, JW5920
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Disease relevance of rcsC

  • Characterization of rcsB and rcsC from Escherichia coli O9:K30:H12 and examination of the role of the rcs regulatory system in expression of group I capsular polysaccharides [1].

High impact information on rcsC

  • Finally, we learned that RcsB and RcsC inversely regulated the timing of flagellar biogenesis: rcsB mutants elaborated flagella prematurely, while rcsC mutants delayed their display of flagella [2].
  • Furthermore, we have identified a mutation in the rcsC gene that decreased the activity of a tolA-lac operon fusion independently of RcsA and partially independently of RcsB activators [3].
  • Sequencing of an rcsC allele, rcsC137, that leads to high-level constitutive expression of both cps and rprA suggests that the response regulator domain of RcsC plays a role in negatively regulating the kinase activity of RcsC [4].
  • Here, we report the cloning and DNA sequence of a 4.3-kb region containing rcsC and rcsB from E. coli O9:K30:H12 [1].
  • Fusions of rcsC to phoA that resulted in PhoA+ strains demonstrated that RcsC is a transmembrane protein with a periplasmic N-terminal domain and cytoplasmic C-terminal domain [5].

Biological context of rcsC


  1. Characterization of rcsB and rcsC from Escherichia coli O9:K30:H12 and examination of the role of the rcs regulatory system in expression of group I capsular polysaccharides. Jayaratne, P., Keenleyside, W.J., MacLachlan, P.R., Dodgson, C., Whitfield, C. J. Bacteriol. (1993) [Pubmed]
  2. Acetyl phosphate-sensitive regulation of flagellar biogenesis and capsular biosynthesis depends on the Rcs phosphorelay. Fredericks, C.E., Shibata, S., Aizawa, S., Reimann, S.A., Wolfe, A.J. Mol. Microbiol. (2006) [Pubmed]
  3. Expression of the tolQRA genes of Escherichia coli K-12 is controlled by the RcsC sensor protein involved in capsule synthesis. Clavel, T., Lazzaroni, J.C., Vianney, A., Portalier, R. Mol. Microbiol. (1996) [Pubmed]
  4. Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli. Majdalani, N., Heck, M., Stout, V., Gottesman, S. J. Bacteriol. (2005) [Pubmed]
  5. RcsB and RcsC: a two-component regulator of capsule synthesis in Escherichia coli. Stout, V., Gottesman, S. J. Bacteriol. (1990) [Pubmed]
  6. Regulation of osmC gene expression by the two-component system rcsB-rcsC in Escherichia coli. Davalos-Garcia, M., Conter, A., Toesca, I., Gutierrez, C., Cam, K. J. Bacteriol. (2001) [Pubmed]
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